摘要
目的探讨氟西汀对老年慢性心力衰竭(CHF)伴抑郁症患者心功能及生活质量的影响。方法将104例老年CHF伴抑郁症患者随机分为两组:对照组(n=52)予以常规抗心衰药物治疗,观察组(n=52)在此基础上加用盐酸氟西汀治疗。评价治疗前后汉密尔顿抑郁量表(HAMD)和明尼苏达心力衰竭生活质量调查表(Li HFe)评分,并测定心功能及血浆B型脑钠肽前体(NT-pro BNP)水平。结果治疗1、3、6个月后,观察组的HAMD评分和Li HFe评分显著低于对照组(P<0.05);治疗3、6个月后,观察组的LVEF、CO、6MWD显著高于对照组,血浆NT-pro BNP显著低于对照组(P<0.05);观察组再入院率、全因死亡率显著低于对照组(P<0.05)。结论氟西汀治疗老年CHF伴抑郁症安全有效,可改善患者的抑郁症状及心功能,提高生活质量并改善临床预后。
Objective To investigate the efficacy of fluoxetine on cardiac function and quality of life in chronic heart failure（CHF）elderly patients with depression. Methods A total of 104 elderly CHF patients with depression were randomly divided into two groups：the control group（n=52）received conventional anti-heart failure drug therapy,while the observation group（n=52）received fluoxetine hydrochloride on this basis. The scores of HAMD and Li HFe were evaluated and the cardiac function indexes and plasma NT-pro BNP were detected before and after treatment. Results At 1 st,3 rd,6 th month after treatment,the HAMD and Li HFe scores in the observation group were significantly lower than those in the control group（P〈0.05）;At 3 rd,6 th month after treatment,the LVEF,CO and 6 MWD in the observation group were significantly higher than those in the control group,the plasma NT-pro BNP were significantly lower（P〈0.05）;The re-admission and all-cause mortality in observation group was significantly lower than that in the control group（P〈0.05）. Conclusion The fluoxetine can improve the depressive symptoms,the quality of life and cardiac function on elderly CHF patients with depression.
作者
白静静
雒娜
王顺达
徐立
BAI Jingfing LUO Na WANG Shunda et al(Shaanxi People ＇s Hospital, Xi＇ an 710068, China)
出处
《国际精神病学杂志》
2017年第5期853-856,共4页
Journal Of International Psychiatry
关键词
慢性心力衰竭
抑郁症
老年
氟西汀
生活质量
Chronic heart failure
Depression
Elderly
Fluoxetine
Quality of life
