摘要
目的探讨复方异丙托溴铵联合布地奈德治疗急诊重症哮喘的效果。方法选取100例急诊重症哮喘患者作为研究对象，遵循单盲随机分配原则分为两组各50例，对照组采用氨茶碱治疗，观察组采用布地奈德联合复方异丙托溴铵雾化吸入治疗，比较两组患者临床疗效、症状缓解时间、动脉血气状况以及肺通气功能。结果观察组总有效率为96％，对照组为80％，差异有统计学意义（x2=6．061，P〈0．05）；相比于对照组的咳嗽（7．39±1．72）d、咳痰（5．17±1．54）d、气促（3．26±1．08）d、哮鸣音（8．43±1．95）d，观察组咳嗽（5．60±1．35）d、咳痰（3．54±1．25）d、气促（1．93±0．87）d、哮鸣音（6．09±1．26）d等症状缓解时间明显缩短（t=5．789、5．811、6．781、7．127，均P〈0．05）；治疗后，观察组动脉血气状况、肺通气功能均显著改善（P〈0．05），且优于对照组治疗后（P〈0．05）。结论在急诊重症哮喘患者中应用布地奈德联合复方异丙托溴铵治疗的临床疗效显著，可加快症状缓解，改善肺通气功能和动脉血气状况。
Objective To study and explore the application effect of compound ipratropium bromide combined with budesonide in acute severe asthma. Methods 100 emergency patients with severe asthma were selected as study subjects,the patients were divided into two groups by following the principles of randomized single blind, each group had 50 cases. The control group received aminophylline treatment, the observation group was treated with budesonide combined with ipratropium bromide inhalation therapy. The clinical curative effect,relieve symptoms, condition of arterial blood gas and pulmonary function were compared between the two groups. Results The total effective rate of the observation group was 96% ,which of the control group was 80% ,the difference was statistically significant（x： =6.061 ,P 〈0.05）. The remission time of cough[ （5.60 ±1.35）d] ,expectoration[ （3.54 ± 1.25） d], shortness of breath[ （ 1.93 ±0. 87 ） d ], wheezing [ （ 6.09 ± 1.26） d ] and other symptoms in the observation group were significantly shorter than those in the control group [ （7.39 ±1.72） d, （5.17 ± 1.54） d, （3.26± 1.08） d, （ 8.43 ± 1.95 ） d ] （ t = 5. 789,5.811,6.781,7.127, all P 〈 0.05 ）. After treatment, the arterial blood gas and lung function in the observation group were significantly improved （ all P 〈 0. 05 ）, which were better than those in the control group after treatment （ all P 〈 0.05 ）. Conclusion The clinical curative effect of budesonide combined with ipratropium bromide in the treatment of patients with severe asthma is significant, it can improve the symptoms, pulmonary ventilation function and arterial blood gas.
作者
常晓英
陈锦华
毕淑珍
李卿
宋彦杰
Chang Xiaoying Chen Jinhua Bi Shuzhen Li Qing Song Yanjie(Department of Emergency, the People＇s Hospital of Changzhi, Changzhi, Shanxi 046000, Chin)
出处
《中国基层医药》
CAS
2017年第21期3254-3257,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
哮喘
布地奈德
复方异丙托溴铵
急诊
Asthma
Budesonide
Compound ipratropium bromide
Emergency
