摘要
非酒精性脂肪肝被认为是代谢综合征的肝脏表现，而且与多种可能增加骨质疏松性骨折的代谢异常情况有关联。然而，对于非酒精性脂肪肝和骨质疏松性骨折的关联尚不明晰。本研究旨在明确非酒精性脂肪肝与骨质疏松性骨折的关联。本研究为观察性研究，共招募7797名40岁以上上海社区居民作为研究对象，进行问卷调查、体格检查、实验室检测和肝脏超声波检查。结果显示在男性中，
Context: Nonalcoholic fatty liver disease (NAFLD) has been considered as a hepatic manifestation of the metabolic syndrome and is associated with various metabolic abnormalities, which may link to an increased risk of osteoporotic fracture. However, epidemiological studies investigating the association between NAFLD and osteoporotic fracture were not available. Objective: The objective of the study was to determine whether NAFLD associates with osteoporotic fracture. Design, Setting, and Participants: This was a cross-sectional study of 7797 Chinese adults aged 40 yr or older in the Jiading District, Shanghai, China. Main Outcome Measures: A questionnaire, anthropometric measurements, laboratory tests, and a hepatic ultrasonic examination were conducted. NAFLD was diagnosed by hepatic ultrasound after the exclusion of alcohol abuse and other liver diseases. A history of fractures was collected with an interviewer-assisted questionnaire. Osteoporotic fractures were defined as fractures that occurred due to low-trauma in 2 yr prior to the study. Results: Among men, the prevalence of osteoporotic fractures was significantly higher in those with NAFLD (3.6 vs. 1.7%, P = 0.003); however, no difference was found in women (3.4 vs. 2.6%, P = 0.14). The presence of NAFLD was significantly associated with increased odds of osteoporotic fracture among men (odds ratio 2.53; 95% confidence interval 1.26-5.07; P = 0.009) after controlling for potential confounders. The significant associations were not detected in women. Conclusions: The presence of NAFLD was significantly associated with a recent history of osteoporotic fracture in middle-aged and elderly Chinese men. (J Clin Endocrinol Metab 97: 2033-2038, 2012)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2017年第11期965-965,共1页
Chinese Journal of Preventive Medicine
