摘要
目的探讨葛根素注射液联合神经节苷脂钠治疗突发性耳聋的临床疗效。方法选取2015年10月—2017年2月在宜兴市人民医院进行治疗的100例突发性耳聋患者为研究对象,根据用药的差别分为对照组(50例)和治疗组(50例)。对照组静脉滴注单唾液酸四己糖神经节苷脂钠注射液,40 mg加入生理盐水100 m L,1次/d。治疗组在对照组的基础上静脉滴注葛根素注射液,400 mg加入生理盐水250 m L,1次/d。两组患者均治疗10 d。评价两组患者临床疗效,同时比较治疗前后两组患者血清细胞因子水平、血液流变学指标和力阈值。结果治疗后,对照组和治疗组总有效率分别为80.00%和96.00%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血浆内皮素(ET)、可溶性血管细胞间黏附分子-1(s VCAM-1)水平降低,降钙素基因相关肽(CGRP)水平增高,同组比较差异具有统计学意义(P<0.05);且治疗组患者血清细胞因子水平显著优于对照组(P<0.05)。治疗后,两组患者血浆黏度(PV)、全血黏度高切(HS)、红细胞聚集指数(EAI)、纤维蛋白原(FIB)均显著降低(P<0.05);且治疗组患者血液流变学指标明显低于对照组(P<0.05)。治疗后,两组患者听力阈值均显著下降(P<0.05);且治疗组患者听力阈值明显低于对照组(P<0.05)。结论葛根素注射液联合神经节苷脂钠治疗突发性耳聋可有效改善血液流变学指标和血管内皮功能,有利于听力恢复,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of Puerarin Injection combined with ganglioside sodium in treatment of sudden deafness. Methods Patients （100 cases） with sudden deafness in Yixing People＆#39;s Hospital from October 2015 to February 2017 were divided into control （50 cases） and treatment （50 cases） groups according to different treatments. Patients in the control group were iv administered with Monosialotetrahexosylganglioside Sodium Injection, 40 mg added into normal saline 100mL, once daily. Patients in the treatment group were iv administered with Puerarin Injection on the basis of the control group, 400 mg added into normal saline 250mL, once daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and serum cytokines, hemorheological indexes and auditory threshold in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 80.00% and 96.00%, respectively, and there were differences between two groups （P 〈 0.05）. After treatment, the ET and sVCAM-1 level in two groups was significantly decreased, CGRP level was significantly increased, and the difference was statistically significant in the same group （P 〈 0.05）. And the serum cytokines in the treatment group were obviously better than that in the control group, with significant difference between two groups （P 〈 0.05）. After treatment, the PV, HS, FIB and EAI in two groups was significantly decreased （P 〈 0.05）, and the hemorheological indexes in the treatment group was significantly lower than that in the control group （P 〈 0.05）. After treatment, the auditory threshold in two groups was significantly decreased （P 〈 0.05）, and the auditory threshold in the treatment group was significantly lower than that in the control group （P 〈 0.05）. Conclusion Puerarin Injection combined with ganglioside sodium can improve the hemorheological indexes and vascular endothelial function in treatment of sudden deafness, and is conducive to the recovery of hearing, which has a certain clinical application value.
作者
王永军
WANG Yong-jun(Department of ENT, Yixing People＇s Hospital, Wuxi 214200, China)
出处
《现代药物与临床》
CAS
2017年第10期1946-1949,共4页
Drugs & Clinic
