摘要
目的:探讨蒿芩清胆汤联合高强度聚焦超声(HIFU)治疗胆囊癌肝转移疗效及其对患者血清免疫球蛋白含量的影响。方法:将医院收治的86例胆囊癌肝转移患者作为研究对象,采用随机数字表法将其平均分为观察组及对照组。所有患者均给予HIFU治疗;观察组在对照组治疗的基础上同时给予蒿芩清胆汤进行治疗,每日1剂,分两次服用,共治疗8周。治疗后,对两组近期疗效及中医证候疗效进行评价;治疗前后,分别检测患者血清AST、ALT、ALP及TBIL含量;治疗前后,分别检测患者血清Ig G、Ig A及Ig M等免疫球蛋白含量。对所有患者进行2年的随访,并观察其6个月生存率、1年生存率及2年生存率;观察所有患者治疗期间各类不良反应。结果:治疗后,观察组近期疗效及中医证候疗效总有效率分别为88.1%和83.3%,均明显高于对照组的75.6%和70.7%,有显著性差异(P<0.05)。治疗后,观察组血清AST、ALT、ALP及TBIL含量均明显低于对照组,有显著性差异(P<0.05)。治疗后,观察组血清Ig G、Ig A及Ig M含量分别为(12.11±1.25)g/L、(2.97±0.40)g/L及(2.31±0.36)g/L,均明显高于对照组,有显著性差异(P<0.05)。观察组1年生存率及2年生存率分别为76.2%和64.3%,均明显高于对照组,有显著性差异(P<0.05)。治疗期间,所有患者均未出现严重不良反应。结论:蒿芩清胆汤联合HIFU治疗胆囊癌肝转移疗效确切,可有效提高患者免疫球蛋白含量,值得进行深入研究。
Objective： To investigate the clinical effects of Haoqin Qingdan Decoction combined with high intensity focused ultrasound in the therapy of hepatic gallbladder carcinoma metastases and its influence on the levels of serum immunoglobulin in patients. Methods ： Eighty - six patients with hepatic gallbladder carcinoma metastases treated in our hospital were selected as the participants and randomly divided into observation group and control group. The control group was treated by high intensity focused ultrasound while the observation group was given Haoqin Qingdan Decoction on the base of control group, one dose a day, twice in the morning and evening, eight weeks for a course. After treatment, the short -term effects and Chinese medical syndrome effects were evaluated in the two groups. Before and after treatment, the levels of AST, ALT, ALP, TBIL, IgG, IgA and IgM were detected in the two groups. The 6 months survival rate, 1 - year survival rate and 2 - year survival rate were observed. And then the complication and toxicity of the two groups were compared. Results ： The total effective rates were 75.6% and 70.7% of short - term effects and Chinese medical syndrome effects in the observation group and were significantly higher than 75.6% and 70.7% in the control group （P 〈 0. 05）. After treatment, the levels of AST, ALT, ALP and TBIL in the observation group were significantly lower than those of the control group （ P 〈 0. 05 ）, while the levels of IgG, IgA and IgM were （ 12.11±1.25 ） g/L, （2.97 ± 0.40） g/L and （2.31 ＋ 0.36） g/L in the observation group, significantly higher than those of the control group （P 〈 0.05 ）. The 1 - year survival rate and 2 - year survival rate were 76.2% and 64.3% in the observation group, significantly higher than those of the control group （ P 〈 0.05 ）. During treatment, there was no serious toxicity in the two groups and the rates of toxieity were similar in the observation group than that in the control group （ P 〉 0.05 ）. Conclusion ： Haoqin Qingdan Decoction combined with high intensity focused ultrasound in the therapy of hepatic gallbladder carcinoma metastases has a good effect and can significantly promot the levels of serum immunoglobulin in patients, worth to the next study.
出处
《中华中医药学刊》
CAS
北大核心
2017年第11期2831-2835,共5页
Chinese Archives of Traditional Chinese Medicine
基金
国家中医药管理局项目[国中医药人教函(2012)228号]
浙江省科学基金项目(2014ZA115)
关键词
蒿芩清胆汤
高强度聚焦超声
胆囊癌肝转移
免疫球蛋白
Haoqin Qingdan Decoction
high intensity focused ultrasound
hepatic gallbladder carcinoma metastases
immunoglobulin
