摘要
目的:调查中医院心肌梗死患者住院期间及随访期间终点事件的发生情况,运用主成分分析结合频数统计构建心肌梗死中医临床疗效评价的终点指标。方法:采用病案调查及随访研究。纳入山东中医药大学附属医院、淄博市中医院、日照市中医院、青岛市中医院、济南市中医院、济宁市中医院6家中医院,2008年1月1日—2014年12月31日入院,出院诊断为心肌梗死患者。制作中医医院心肌梗死患者调查表。收集患者住院期间及随访期间一般资料及终点事件发生情况。将数据输入Excel2003及SPSS17.0软件包。运用主成分分析分别计算住院期间及随访期间各终点指标的权重,统计各指标发生频数,利用乘数合成归一法计算各指标的综合权重,结合临床意义,建立心肌梗死中医临床疗效评价的终点指标。结果:(1)住院期间:综合权重大小依次为梗死后心绞痛(0.2175)、血运重建(0.1624)、心源性死亡(0.1360)等。(2)随访期间:随访6个月内综合权重大小依次为再住院次数(0.3887)、梗死后心绞痛(0.149)、心源性死亡(0.1434)等。随访1年内综合权重大小依次为再住院次数(0.5229)、心源性死亡(0.1271)、梗死后心绞痛(0.1212)等。随访1年以上综合权重大小依次为再住院次数(0.4374)、再梗死(0.1702)、心源性死亡(0.17)等。结论:(1)住院期间:主要评价指标为心源性死亡、严重心律失常、急性心力衰竭,次要评价指标为心源性休克、梗死后心绞痛、血运重建。(2)随访期间:随访6个月内主要评价指标为心源性死亡、心力衰竭、严重心律失常,次要评价指标为再梗死、脑卒中、血运重建等。随访1年内主要评价指标为心源性死亡、再梗死、心力衰竭,次要评价指标为脑卒中、血运重建、梗死后心绞痛等。随访1年以上主要评价指标为再梗死、心源性死亡、严重心律失常,次要评价指标为脑卒中、梗死后心绞痛、血运重建等。
Objective：To investigate the incidence of endpoints of patients with myocardial infarction during hospitalization and follow up in traditional Chinese medicine hospital,to construct the endpoints of the clinical efficacy evaluation of TCM in patients with myocardial infarction based on the principal component analysis combined with frequency statistics.Methods：Using the medical record investigation and follow-up study.Patients with acute myocardial infarction（AMI） admitted to hospital on January 1,2008 to December 31,2014 in the Affiliated Hospital of Shandong University of TCM,Zibo,Rizhao,Qingdao,Jinan,Jining Hospital of TCM was included.The occurrence of general information and endpoint events during hospitalization and follow-up period were collected.Data were input Excel2003 and SPSS 17.0 software package.The weights of the endpoints during hospitalization and follow-up are calculated by using principal component analysis and statistics of each index occurrence frequency,to construct the endpoints of the clinical efficacy evaluation of TCM in patients with myocardial infarction combined with clinical significance.Results：1.Hospitalization period：Comprehensive weight order is post infarction angina（0.2175）,Reconstruction of blood circulation（0.1624）,Cardiac death（0.1360）,Severe arrhythmia（0.1299）,heart failure（0.1063）.2.Follow-up period：Comprehensive weight order during the follow-up period of 6 months are number of re hospitalization（0.3887）,angina pectoris（0.149）,cardiac death（0.1434）.Comprehensive weight order during the follow-up period of 1 years are number of re hospitalization（0.5229）,cardiac death（0.1271）,and angina pectoris（0.1212）.Comprehensive weight order during follow up for more than 1 years are Re hospitalization（0.4374）,re infarction（0.1702）,cardiac death（0.17）.Conclusion：1.Hospitalization period：Main evaluation index are Cardiac death,Severe arrhythmia,heart failure,Secondary evaluation index are Cardiac shock,Post infarction angina.2.Follow-up period：Main evaluation index are Cardiac death,heart failure,severe arrhythmia,secondary evaluation index are Re infarction,stroke,revascularization during the follow-up period of 6 months.Main evaluation index are Cardiac death,re infarction,heart failure,Secondary evaluation index are Stroke,revascularization,post infarction angina during the follow-up period of 1 years.Main evaluation index are Re infarction,cardiac death,severe arrhythmia,secondary evaluation index are Stroke,post infarction angina,revascularization during follow up for more than 1 years.
作者
高武霖
戴国华
史晓静
赵芳
盛原羽
GAO Wulin DAI Guohua SHI Xiaojing ZHAO Fang SHENG Yuanyu(First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Department of Heart Disease,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicin)
出处
《辽宁中医杂志》
CAS
北大核心
2017年第10期2021-2025,共5页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81373827)
山东省一流学科资助项目(中医学)
关键词
主成分分析
心肌梗死
中医临床疗效评价
终点指标
principal component analysis
myocardial infarction
clinical evaluation of TCM
Endpoint
