摘要
目的探讨不同剂量万古霉素骨水泥对膝关节置换患者术后感染的影响。方法回顾性调查研究某医院骨科2013年1月至2015年3月283例初次膝关节置换术的病例。结果共纳入283例初次膝关节置换术的病例,其中206患者在术中使用1 000 mg万古霉素抗生素骨水泥,另外77例患者在术中使用2 000 mg万古霉素抗生素骨水泥。两组患者的年龄、体重、糖尿病、初始诊断、HSS术前术后评分、住院时间比较差异无统计学意义(P>0.05);采用双项Logistic相关性分析膝关节置换患者感染因素,显示不同剂量万古霉素、性别、体重、基础诊断、住院天数对膝关节置换后感染无影响,而糖尿病是膝关节置换术后感染的高危因素。结论初次膝关节置换患者预防性应用1 000 mg或2 000 mg万古霉素骨水泥,在术后再发感染方面无显著差异,为减少抗菌药物不良反应和减轻患者治疗经济负担,可预防性应用1 000 mg万古霉素骨水泥。
Objective To evaluate the efficacy of different doses of vancomycin bone cement for patients with joint replacement. Methods Totally 283 patients who accepted the joint replacement for the first time from January2013 to March 2015 in the hospital were included and analyzed retrospectively. Results Totally 206 patients used1 000 mg vancomycin bone cement to prevent infection, and the other 77 patients used 2 000 mg. There was no significant difference in the age,weight, the number of diabetes, initial diagnosis, the HSS scores before or after operation（ P〈0. 05）. The result of logistic analysis showed that dose of vancomycin bone cement,gender,body weight,basic diagnosis and length of hospital stay had no influence on the incidence of infection after joint replacement. However diabetes is a risk factor of infection. Conclusion There is no significant difference in the recurrence of infection between prophylactic use of 1 000 mg and 2 000 mg vancomycin bone cement in patients receiving joint replacement for the first time. To reduce the adverse reactions of antibiotic drugs and the economic burden of patients,1 000 mg prophylactic use of vancomycin bone cement should be suggested.
作者
付曼曼
董瑶漪
任天舒
FU Man-man DONG Yao-yi REN Tian-shu(Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110016, China)
出处
《实用药物与临床》
CAS
2017年第10期1156-1158,共3页
Practical Pharmacy and Clinical Remedies
关键词
万古霉素
骨水泥
感染
Vancomycin
Bone cement
Infection
