摘要
目的:探讨利福平耐药实时荧光定量核酸扩增技术(Xpert Mtb/RIF)对结核病的诊断价值。方法:261例疑似结核病患者作为研究对象,均进行Xpert Mtb/RIF和痰涂片实验室检查,以影像学检查联合细菌学检查进行确诊,比较两组检查方法的诊断价值。结果:Xpert Mtb/RIF检查准确率(198例,75.86%)明显高于痰涂片检查(160例,61.30%),差异有统计学意义(P<0.05);并且Xpert Mtb/RIF检查的灵敏度(69.04%)、特异度(96.88%)、约登指数(0.659)、阳性预测值(98.55%)和阴性预测值(50.41%)均高于痰涂片检查(分别为51.27%、92.19%、0.435、95.28%和38.06%)。结论:Xpert Mtb/RIF检查方法对结核病诊断具有较高价值,有助于结核病的早期诊断和治疗。
Objective： To explore the diagnostic valuation of Xpert Mtb/RIF detection test for tuberculosis. Methods： 261 patients of tuberculosis were selected as the object of study. All patients were examined by Xpert Mtb/RIF and sputum smear detection test, and the imaging examination combined bacteriological examination was diagnosed with tuberculosis. The diagnostic valuation of Xpert Mtb/RIF and sputum smear detection test was compared. Results：The accuracy of Xpert Mtb/RIF detection test （198 cases, 75.86%） was significantly higher than sputum smear （160 cases, 61.30%） for tuberculosis diagnosis （P〈O.05）. The sensitivity （69.04%）, speci- ficity （96.88%）, Youden index （0.659）, positive predictive value （98.55%） and negative predictive value （50.41%） of Xpert Mtb/RIFdetection test were higher than sputum smear （51.27%, 92.19%, 0.435, 95.28% and 38.06% respectively）. Conclusion： Xpert Mth/ RIF detection test has a high diagnostic valuation for tuberculosis, helping the early diagnosis and treatment of tuberculosis.
作者
班立芳
Ban Lifang(Department of laboratory medicine, the sixth People＇s Hospital of Zhengzhou （Henan Zhengzhou 450061)
出处
《黑龙江医药》
CAS
2017年第2期277-279,共3页
Heilongjiang Medicine journal
