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Fish检测舌鳞状细胞癌中EGFR基因扩增及临床应用价值初步研究

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摘要 目的 探讨表皮生长因子受体(EGFR)在舌鳞状细胞癌病变中基因扩增及临床意义.方法 选取齐齐哈尔市第一医院2005年1月~12月手术切除并经病理诊断的舌鳞状细胞癌患者156例为研究对象,用荧光原位杂交(FISH)技术检测EGFR基因的扩增情况,并进一步分析EGFR基因扩增与患者临床病理生理特征的关系.结果 FISH结果显示,46.2%(72/156)的舌鳞状细胞癌患者存在EGFR基因扩增,而EGFR基因的扩增与患者的性别、年龄、吸烟状态、饮酒状态及是否存在转移无关,差异无统计学意义(P〉0.05).结论 EGFR基因扩增与患者性别、吸烟饮酒状态、等临床特征无明显关系,与患者预后的相关性及舌鳞状细胞癌的临床应用价值有待进一步研究.
出处 《全科口腔医学电子杂志》 2016年第4期48-49,共2页 Electronic Journal of General Stomatology
基金 齐齐哈尔市科学技术计划项目。编号:SFGG-201445
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