摘要
目的评价西吡氯胺口含片、丁硼乳膏、复方氯己定含漱液三种药物对正畸牙龈炎患者龈沟液中MMP-3及IL-1β水平的影响。方法选取80例正在进行固定矫治且伴有牙龈炎的患者,随机分为四组,分别应用西吡氯胺口含片,丁硼乳膏,复方氯己定含漱液干预,对照组仅进行全口超声洁治术后普通日常维护,于不同时段采集患者龈沟液,ELISA法对其中MMP-3及IL-1β用药前后指标的变化进行检测。结果四组患者MMP-3浓度治疗前比较差异无统计学意义(P>0.05),治疗后浓度比较差异有统计学意义(P<0.05),实验组明显降低。四组患者IL-1β浓度治疗前比较差异无统计学意义(P>0.05),治疗后浓度比较差异有统计学意义(P<0.05),实验组明显降低。结论三种不同药物对正畸性龈炎均有治疗效果。其中西吡氯胺口含片的抑菌效果优于其它两种传统药物,丁硼乳膏优于复方氯己定含漱液,复方氯己定含漱液抑菌效果相对较差。
Objective To evaluate effect of the concentration of IL-1β and MMP-3 in gingival sulcus fluid of orthodontic gingivitis by used cetylpyridinium chloramine buccal tablets,Cremor Oleiocimi Gratissimi Et Boracis and compound chlorhexidine gargle.Methods 80 cases orthodontic gingivitis were randomly divided into four groups,respectively used cetylpyridinium chloramines buccal tablets,small boron cream and compound chlorhexidine gargle,the control group only full-mouth ultrasonic scaling and general maintenance,collected gingival sulcus fluid at different times,then detected changes of MMP-3 and IL-1β by ELISA.Result The concentration of MMP-3 and IL-1 β of the 4 groups before treatment had no statistically significant difference,then the concentration difference was statistically significant after treatment,and decreasing trend is more obvious in the experimental group.Conclusion There have a therapeutic effect that three different drugs were used in orthodontic gingivitis.The effect of cetylpyridinium chloramine buccal tablets is the best of thee traditional medicines,the effect of Cremor Oleiocimi Gratissimi Et Boracis is better than compound chlorhexidine gargle,effect of compound chlorhexidine gargle antibacterial is relatively poor.
作者
黄荣花
冯云霞
范红
任娟
孟国华
HUANG Rong-Hua FENG Yun-Xia FAN Hong REN Juan MENG Guo-Hua(Department of oral medicine in Shanxi Medical University, Shan Xi Taiyuan 030001, China Department of oral and orthodontic treatment in Shan Xi People’s Hospital, Shan Xi Taiyuan, 030012, China Department of Stomatology, Central Hospital of Berlin District, Shan Xi Taiyuan 030024, China)
出处
《全科口腔医学电子杂志》
2016年第1期29-32,共4页
Electronic Journal of General Stomatology
关键词
正畸
龈炎
西吡氯胺口含片
金属基质蛋白酶-3
白介素-1Β
Orthodontic gingivitis
Cetylpiridinium chloramine buccal tablets
Matrix metalloproteinase-3
Interleukin-1 β
