摘要
高尿酸血症发病率逐年上升,与痛风、心脑血管疾病、代谢综合征等疾病均有相关关系。禽类动物尿酸代谢途径与人类相似,诱发及自发高尿酸血症较为常见,因而在高尿酸血症模型研究方面地位日益突出。本文对近30余年禽类高尿酸血症报道及实验研究进行综述,以期阐明禽类动物高尿酸血症模型发病特点与机制。
The incidence of hyperuricemia increases year by year. Hyperuricemia is associated with gout,cardiovascular disease,metabolic syndrome,etc. The metabolic pathway of uric acid is similar in human and avian species. Experimental or spontaneous hyperuricemia is commonly happened in avian. So that avian species have been used in biological or medicinal research increasingly. In this article,we reviewed the literature of avian hyperuricemia and experimental studies over the last 30 years,and to elucidate the characteristics and mechanisms of avian hyperuricemia models.
出处
《中国实验动物学报》
CSCD
北大核心
2017年第5期572-576,共5页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金(No.81673618
81403152)
北京市自然科学基金(No.7162117)
