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联合内窥镜下局部注射丝裂霉素治疗食管良性狭窄效果观察 被引量:4

Efficacy observation of local injection of mitomycin under endoscope for treatment of benign esophageal stricture
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摘要 目的 观察内窥镜下狭窄部位局部注射丝裂霉素(MMC)治疗食管癌术后吻合口狭窄或食管内窥镜黏膜下剥离术(ESD)的疗效和安全性.方法 选取食管狭窄患者48例,分组给予扩张联合放射状切开结合或不结合局部注射MMC,评估治疗前后食管直径改善情况,同时对MMC治疗组和对照组之间的疗效进行比较.结果 ESD术后狭窄中,MMC组治疗后狭窄部位直径由(0.26±0.14)cm增至(1.07±0.12)cm,与对照组[治疗后(0.25±0.13)cm增至(0.78±0.07)cm]比较,差异有统计学意义(t=5.63,P〈0.05).食管吻合口狭窄中,MMC组治疗后直径由(0.33±0.13)cm增至(1.02±0.13)cm,与对照组[治疗后(0.35±0.10)cm增至(0.97±0.10)cm]比较,差异无统计学意义(t=1.22,P〉0.05).其中MMC组有2例患者出现食管瘘,分别置入支架.结论 局部注射MMC对食管ESD术后狭窄的疗效显著,但需谨慎操作,避免并发症的发生.
出处 《肿瘤研究与临床》 CAS 2017年第10期698-700,共3页 Cancer Research and Clinic
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