摘要
目的探讨实时剪切波弹性成像(SWE)技术对桥本甲状腺炎(HT)患者服用强的松后疗效评价的临床应用价值。方法应用SWE技术测量45例临床确诊为HT所致亚临床甲减状态的患者应用强的松治疗前和治疗1个月后的甲状腺组织的各项杨氏模量值,并用配对t检验分析比较其治疗前后的差异。结果应用强的松治疗前和治疗1个月后对比,患者甲状腺组织杨氏模量值及血清促甲状腺激素(TSH)浓度、甲状腺过氧化物酶抗体(TPOAb)及抗甲状腺球蛋白抗体(TGAb)差异均有统计学意义(P<0.05),治疗后患者的各项模量值均有不同程度的降低,并且患者的血清TSH均恢复正常。结论通过SWE定量测量甲状腺组织的杨氏模量值可获得客观的组织硬度信息,为评价强的松对HT患者的治疗效果及病情进展情况提供更有意义的参考依据,具有重要的影像学及临床研究价值。
Objective To investigate the clinical application value of the real-time shear wave elastography(SWE)technology in the curative evaluation on Hashimoto′ s thyroiditis(HT)patients treated with prednisone.Methods Applying SWE technology to determine the Young′s modulus value of thyroid tissue of 45 HT caseswith subclinical hypothyroidism before and one month after treatment. Results 1 month after prednisone treat-ment,the Young′s modulus value and serum thyroid stimulating hormone(TSH),thyroid-peroxidase antibody(TPOAb)and thyroglobulin antibody(TGAb)were observed significantly changed before and one month aftertreatment(P < 0.05,respectively). The various modulus value was found reduced with different degrees,but theserum TSH was shown back to normal after the treatment with prednisone. Conclusions By quantitative determi-nation of Young′s modulus value,the hardness of organization information was obtained objectively,which couldprovide more meaningful reference basis to evaluate the treatment of prednisone for HT.
出处
《实用医学杂志》
CAS
北大核心
2017年第21期3627-3630,共4页
The Journal of Practical Medicine
基金
山东省卫生和计划生育委员会科技计划项目(编号:2014-38)
关键词
桥本甲状腺炎
实时剪切波弹性成像
强的松
杨氏模量
亚临床甲减
Hashimoto thyroiditis
real-time shear wave elastography
prednisone
Young's modulus
subclinical hypothyroidism
