摘要
目的探讨手术联合术前后放化疗治疗直肠癌的临床疗效。方法将186例行手术治疗的直肠患者分为观察组和对照组,对照组患者术后给予放化疗,而观察组在术前后均进行放化疗,观察两组肿瘤降期情况、临床症状改善情况、生活质量、放化疗耐受性、血清肿瘤标志物水平及保肛率,随访3年,比较两组局部复发率及总生存率。结果观察组患者术前肿瘤降期比例及临床症状积分均高于对照组,组间差异有统计学意义(P<0.05)。观察组生活质量改善情况、保肛率及血清肿瘤标志物水平均优于对照组,组间差异有统计学意义(P<0.05)。随访3年,观察组中位生存时间、3年局部复发率及总生存率均优于对照组,组间差异有统计学意义(P<0.05)。结论手术联合术前后放化疗能有效降低术前肿瘤分期,提高患者手术治疗效果及生活质量,减少术后局部复发,提高远期生存率。
Objective To explore the clinical efficacy of surgical resection combined with preoperative radio -chemother-apy for rectal cancer.Methods 186 patients with rectal cancer were divided into the control group and the observation group ,in-cluding 97 patients who received preoperative and postoperative radio-chemotherapy plus surgery （ the observation group ） and 89 patients who received postoperative radio-chemotherapy plus surgery （ the control group ） ,stage of tumor ,clinical symptoms ,the in-cidence of radio-chemotherapy tolerance , the rate of sphincter preservation , quality of life and level of tumor marker were ob-served.Follow up for 3 years,the rate of local recurrence and the rate of overall survival in the 2 groups were compared.Results The observation group was significantly higher than the control group in the reduction ratio of tumor stage and clinical symptom score（P〈0.05）.The observation group was significantly better than the control group in KPS score ,the rate of sphincter preser-vation and the level of tumor marker （P〈0.05）.Follow up for 3 years,the observation group was significantly better than the con-trol group in the rate of local recurrence ,3-year survival rate and the median survival time （P〈0.05）.Conclusion Preoperative radio-chemotherapy can significantly reduce the stage of tumor ,improve the effect of surgical treatment and quality of life ,reduce postoperative local recurrence and improve long-term survival rate.
出处
《实用癌症杂志》
2017年第1期74-77,共4页
The Practical Journal of Cancer
关键词
新辅助化疗
直肠癌
临床疗效
Neoadjuvant therapy
Rectal cancer
Clinical efficacy
