摘要
综述了目前法规认可的国内外化妆品刺激性评价的体内和体外替代方法,重点从原理、方法、应用等方面介绍了眼睛、皮肤刺激/腐蚀性评价体外替代方法,共包括9种眼刺激/腐蚀性、3种皮肤腐蚀性、1种皮肤刺激性评价方法。最后提出体外替代方法虽然有待进一步成熟,但已经成为全球发展趋势,而我国应结合国情积极建立相应的体外替代方法。
The in vivo and in vitro alternative methods of irritation evaluation for cosmetics approved by regulations at home and abroad were reviewed. The principles, methodology and applications of in vitro alternatives methods for eye and skin irritation/corrosion evaluation were described in detail, including 9 methods for eye irritation/corrosion, 3 methods for skin corrosion, 1 method for skin irritation. Finally, it concluded that the alternative methods in vitro had become a global trend. And we should actively establish the corresponding in vitro alternative methods upon national situations.
出处
《香料香精化妆品》
CAS
2017年第5期69-74,共6页
Flavour Fragrance Cosmetics
关键词
刺激性
体内
体外
替代方法
irritation
in vivo
in vitro
alternative method
