摘要
目的探讨南宁地区壮族、汉族正常人群骨密度(bone mineral density,BMD)、峰值骨量(peak bone density,PBD)以及随增龄骨丢失率(rate of bone loss,RBL)的规律及临床意义。方法使用美国Hologic公司生产的双能X线吸收仪(dual energy X-ray absorptiometry,DAX),对南宁地区壮族、汉族正常体检人群的20899名的腰椎L1~4、左股骨颈上段BMD进行测定,按检测不同部位、性别、年龄分组统计出PBD的均值±标准差和RBL(%)。参照WHO的规定,对≥50岁男性和绝经后女性与本数据库人群中同性别、同部位PBD比较,-2.5<T值<-1.0为骨量减少,T值≤-2.5为骨质疏松。结果 (1)各部位PBD出现在25~27岁,腰椎PBD男性为1.066±0.153,女性为1.025±0.095;左股骨颈上段PBD,男性为0.920±0.136,女性为0.796±0.132。(2)女性在47岁前BMD处于平台期,围绝经后BMD加速丢失,以腰椎尤为显著,年RBL在1.13%~2%;男性累计RBL随年龄逐渐上升,年丢失率约在0.21%~0.68%,但各年龄段左股骨颈上段的RBL始终高于腰椎。(3)以本地区人群数据库作为参照,男性骨质疏松检出率为腰椎3.1%,左股骨颈上段9.47%;女性腰椎48.8%,左股骨颈上段5.02%。结论南宁地区老年人发生骨质疏松性骨折风险女性明显高于男性,女性的腰椎、男性的股骨颈可能骨折风险更高。
Objective To investigate the clinical significance of bone mineral density（BMD）,peak bone density（PBD）,and the rate of bone loss（RBL） in normal people of Zhuang and Han nationalities of Nanning area.Methods BMD of the lumbar vertebrae L1-L4 and the left femoral neck was measured in 20899 cases of normal people in Nanning area by using dual energy Xray absorptiometry（DAX,Hologic,USA）.PBD and RBL were calculated according to different locations,gender,and age.According to the WHO criteria,compared with the local PBD of our database,-2.5T-1.0 was diagnosed as bone loss and T≤-2.5 was diagnosed as osteoporosis,in males over 50 years old and postmenopausal women.Results（1） PBD appeared at the 25-27 years old.In the lumbar vertebrae,it was 1.066±0.153 in males and 1.025±0.095 in females,respectively.In the left femoral neck,it was 0.920±0.136 in males and 0.796±0.132 in females,respectively.（2） BMD in females was stable before 47 years old.It accelerated to loss after menopause,particularly in the lumbar vertebrae,with annual RBL of 1.13%-2%.RBL increased gradually with age in males.The annual loss rate was 0.21%-0.68%.RBL at the left femoral neck was always higher than that at the lumbar vertebrae.（3） Referred to the local database,the detection rate of osteoporosis in males was 3.1% in the spine,9.47% in the left femoral neck,respectively.It was 48.8% in the spine,5.02% in the left femoral neck,respectively,in females.Conclusion The risk of osteoporotic fractures in the elderly women is significantly higher than that in men.Women are more likely to suffer from osteoporotic fractures in the spine,but men are more likely to suffer from that in the femoral neck.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2017年第11期1507-1511,共5页
Chinese Journal of Osteoporosis
