摘要
目的观察金匮肾气丸对阳虚型亚临床甲状腺功能减退症(SCH)患者甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)及甲状腺功能的影响。方法将90例阳虚型SCH患者随机分为3组,中药组30例予金匮肾气丸治疗,西药组30例予左甲状腺素钠片常规治疗,对照组30例予以观察。3组均1个月为1个疗程,3个疗程后观察3组治疗前后TPOAb、TGAb滴度及甲状腺功能[游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、促甲状腺激素(TSH)]的水平变化。结果 3组治疗前后FT3、FT4组内及组间比较差异均无统计学意义(P>0.05);中药组、西药组治疗后TSH与本组治疗前及对照组治疗后比较差异均有统计学意义(P<0.05),但中药组、西药组治疗后组间比较差异无统计学意义(P>0.05)。中药组、西药组治疗后TPOAb与本组治疗前及对照组治疗后比较差异均有统计学意义(P<0.05),且中药组较西药组疗效更佳(P<0.05)。中药组治疗后TGAb与本组治疗前有所下降,比较差异有统计学意义(P<0.05),而西药组及对照组治疗后TGAb与本组治疗前比较差异均无统计学意义(P>0.05)。结论金匮肾气丸可降低阳虚型SCH患者TSH水平,从而一定程度上调节患者的激素水平。
Objective To observe the effects of Jingui-shenqi pills on thyroid peroxidase antibody( TPOAb),thyroglobulin antibodies( TGAb) and thyroid function in subclinical hypothyroidism( SCH) patients with yang-deficiency type. Methods 90 SCH patients with yang-deficiency type were randomly divided into three groups.30 cases in the traditional Chinese medicine( TCM) group were treated by Jingui-shenqi pills,and 30 cases in the western medicine group were treated by Euthyrox,and 30 cases in the control group were observed. A treatment course was 1 month in three group that continuously treatment for three courses. The levels of TPOAb,TGAb titer,and thyroid function including the free triiodothyronine( FT3),free tetraiodothyronine( FT4) and thyroid stimulating hormone( TSH) before and after 3 treatment courses were observed in there groups. Results There was no statistical difference on FT3 and FT4 between-group and intra-group( P > 0. 05). There statistical differences on TSH between before and after treatment in the TCM group and the western medicine group,and there statistical differences on TSH after treatment among the TCM group,the western medicine group and the control group( P < 0. 05). There was no statistical difference on TSH after treatment between the TCM group and the western medicine group( P >0. 05). There statistical differences on TPOAb between before and after treatment in the TCM group and the western medicine group, and there were statistical differences on TPOAb after treatment among the TCM group,the western medicine group and the control group( P < 0. 05),and the effects in the TCM group and the western medicine group were much better( P < 0. 05). The TGAb after treatment was reduced in the TCM group( P < 0. 05). There was no statistical difference on TGAb between before and after treatment in the western medicine group and the control group( P > 0. 05). Conclusion Jinkui-shenqi pills can regulate the status of SCH patients with yang-deficiency typein a certain degree.
作者
郑粤文
贾燕飞
罗瑞钦
ZHENG Yuewen;JIA Yanfei;LUO Ruiqin.(Department of IDistrict Hospital of Traditional Chinese Medicine in Shenzhen City, Guangdong Province,Guangdong, Shenzhen 518001)
出处
《河北中医》
2017年第10期1473-1476,共4页
Hebei Journal of Traditional Chinese Medicine
基金
广东省深圳市科技创新基金项目(编号:JCYJ20150402100915083)
关键词
甲状腺功能减退症
金匮肾气丸
中药疗法
Subclinical Hypothyroidism
Jinkui-shenqi pills
Traditional Chinese medicine therapy
