摘要
目的:探讨维生素D联合阿奇霉素治疗2型糖尿病患者肺炎的临床疗效和安全性,及其对血清炎症指标的影响。方法:选取我院2014年5月-2015年9月收治的2型糖尿病伴肺炎患者68例,按照随机数字表法将患者分为对照组和试验组,各34例。两组患者均给予胰岛素强化降糖。对照组患者给予注射用阿奇霉素10 mg/kg+0.9%氯化钠注射液500 m L,ivgtt,qd,连续应用5 d后改用阿奇霉素干混悬剂10 mg/kg,po,qd,连用3 d后停药4 d为1个疗程,给药2个疗程;试验组患者在对照组基础上给予维生素D滴剂800单位,po,qd,连续给药4周。观察两组患者的临床疗效、治疗前后的血清炎症指标[白细胞介素6(IL-6)、C反应蛋白(CRP)和免疫球蛋白G(Ig G)]水平,并记录不良反应发生情况。结果:试验组患者临床总有效率(91.18%)显著高于对照组(70.59%),差异有统计学意义(P<0.05)。治疗前,两组患者IL-6、CRP和Ig G等血清炎症指标比较,差异均无统计学意义(P>0.05)。治疗后,两组患者IL-6和CRP均显著降低,且试验组显著低于对照组;两组患者Ig G显著升高,且试验组显著高于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:维生素D联合阿奇霉素治疗2型糖尿病患者肺炎的临床效果显著,有助于改善其血清IL-6、CRP和Ig G等炎症因子水平,且安全性较高。
OBJECTIVE： To investigate clinical efficacy and safety of vitamin D combined with azithromycin in the treatment of pneumonia in patients with type 2 diabetes and its effects on serum inflammation indexes. METHODS ： A total of 68 patients with type 2 diabetes complicated with pneumonia selected from our hospital during May 2014-Sept. 2015 were divided into control group and trial group according to random number table, with 34 cases in each group. Both groups received insulin intensive hypo- glycemic therapy. Control group was given Azithromycin for injection 10 mg/kg＋0.9% Sodium chloride injection 100 mL, ivgtt, qd, for consecutive 5 d, and then used Azithromycin dry suspension instead 10 mg/kg, po, qd, consecutive 3 d treatment and 4 d interval as a treatment course, for 2 cycles. Trial group was additionally given Vitamin D drops 800 U, po, qd, for consecutive 4 weeks, on the basis of control group. The clinical efficacies of 2 groups were observed, and serum inflammation indexes [interleu- kin-6 （IL-6）, C-reactive protein （CRP）, immunoglobulin G protein （IgG）] levels were also observed before and after treatment. The occurrence of ADR was recorded. RESULTS： Total response rate of trial group （91.18%） was significantly higher than that of control group （70.59%）, with statistical significance （P〈0.05）. Before treatment, there was no statistical significance in serum inflammation indexes as IL-6, CRP, IgG between 2 group （P〉0.05）. After treatment, IL-6 and CRP of 2 groups were decreased sig- nificantly, and the trial group was significantly lower than the control group; IgG of 2 groups were increased significantly, and the trial group was significantly higher than the control group, with statistical significance （P〈0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P〉0.05）. CONCLUSIONS： Vitamin D combine with azithromycin in the treatment of pneumonia in patients with type 2 diabetes has a good clinical curative effect, helps to improve the levels of IL-6, CRP and IgG with good safety.
出处
《中国药房》
CAS
北大核心
2017年第32期4524-4526,共3页
China Pharmacy
基金
唐山市科技计划项目(No.121302126a)
