摘要
目的探讨全麻诱导时喷他佐辛预处理减少依托咪酯诱发肌阵挛的效果。方法 80例择期行腹腔镜下胆囊切除术患者随机分为喷他佐辛组(P组)与对照组(C组)。比较2组用药前(T0)、静注喷他佐辛或生理盐水后1 min(T1)、静注依托咪酯后1 min(T2)、2 min(T3)的平均动脉压(MBP)、心率(HR)、Sp O2。在静注依托咪酯后,观察2 min内肌阵挛阳性率及发生分级。苏醒拔除喉罩后5、10及30 min,2组进行VAS评分。比较2组不良反应发生情况。结果 2组患者性别构成比、年龄、体质量和ASA分级构成比无显著差异(P>0.05)。与C组相比,P组患者T1、T2、T3MBP和HR显著升高(P<0.05)。P组苏醒后5、10及30 min的VAS评分均显著低于C组(P<0.05)。2组肌阵挛严重程度及发生率比较有显著差异(P<0.05)。2组患者围术期未发现头晕、头痛、恶心、呕吐及注射痛等其他明显的不良反应。结论全麻诱导时预注喷他佐辛可以有效地减少依托咪酯诱导时导致的肌阵挛。
ObjectiveTo investigate the effect of pretreatment of pentitrexacin on reducing myoclonus induced by etomidate during general anesthesia. MethodsA total of 80 patients undergoing elective laparoscopic cholecystectomy were randomly divided into control group （group P） and control group （group C）. MBP, HR, and SpO2 were measured before drugs administration（T0）, after 1 min of intravenous injection of pentazocine or saline （T1）, after 1 min （T2）, 2 min （T3） of intravenous injection of etomidate. After intravenous injection of etomidate, the positive rate of myoclonus in 2 min and its gradings were observed. The VAS scoring was carried out in the 2 groups at 5, 10 and 30 min after the removal of the laryngeal mask. Adverse reactions occurred of two groups were compared. ResultsThere were no significant differences in sex ratio, age, body mass and ASA grading ratio between the two groups （P〉0.05）. Compared with group C, the mean arterial pressure and heart rate at T1, T2 and T3 in group P were significantly higher than that in group C （P〈0.05）. The VAS scores of group P were significantly lower than that of group C at 5, 10 and 30 min after awakening （P〈0.05）. There were significant differences in the severity and incidence of myoclonus between the two groups （P〈0.05）. There was no dizziness, headache, nausea, vomiting and injection pain and other obvious adverse reactions of two groups in perioperative period. ConclusionPretreatment of pentitrexacin in general anesthesia can effectively reduce myoclonus induced by etomidate induction.
作者
刘松
谢杰
吴佐满
李晓华
郭祥冲
LIU Song;XIE Jie;WU Zuoman;LI Xiaohua;GUO Xiangchong(Department of Anesthesiology;Department of Pathology and Medical Laboratory, Affiliated Aoyang Hospital of Jiangsu University, Zhangjiagang, Jiangsu, 215618)
出处
《实用临床医药杂志》
CAS
2017年第19期77-79,83,共4页
Journal of Clinical Medicine in Practice
基金
国家自然科学基金资助项目(81572741)
关键词
依托咪酯
全麻诱导
预注
喷他佐辛
肌阵挛
etomidate
general anesthesia induction
pre injection
pentazocine
myoclonus
