摘要
目的:观察中药复方治疗分化型甲状腺癌术后患者血清甲状腺球蛋白(TG)浓度和甲状腺球蛋白抗体(TG-Ab)浓度的变化。方法:将纳入观察的96例患者随机分成2组各48例,观察组采用中药联合左旋甲状腺素片(L-T4)进行治疗,对照组单纯采用L-T4治疗,治疗周期为3月。治疗开始时检测外周血TG浓度、TG-Ab浓度及安全性指标肝肾功能、甲状腺功能,治疗结束后再次检测外周血TG、TG-Ab浓度及安全性指标游离三碘甲腺原氨酸(FT3)、游离四碘甲腺原氨酸(FT4)、门冬氨酸转移酶(AST)、谷丙转氨酶(ALT)、血清肌酐(SCr)。比较TG及TG-Ab浓度的变化。结果:治疗后,观察组外周血、TG-Ab与对照组比较,差异有统计学意义(P<0.01)。治疗后,观察组全切患者TG对照组比较,差异有统计学意义(P<0.01);观察组次全切、全切患者TG-Ab分别与对照组比较,差异均有统计学意义(P<0.01)。不良反应情况,2组治疗前后肝肾功能指标ALT、AST、SCr,甲状腺功能指标T4、T3、FT4、FT3等与治疗前比较,差异无统计学意义(P>0.05);治疗后,2组ALT、AST、SCr、T4、T3、FT4、FT3比较,差异均无统计学意义(P>0.05)。提示2组治疗方法具有一定的安全性。结论:中药复方治疗分化型甲状腺癌术后患者,能改善患者TG和TG-Ab情况,且具有一定的安全性。
Objective- To observe changes of concentrations of serum thyroglobulin （TG） and thyroglobulin antibody （TG-Ab） in postoperative differentiated thyroid carcinoma patients treated with compound Chinese medicine. Methods. Divided 96 cases of patients into two groups randomly, 48 cases in each group. The observation group was treated with Chinese medicine combined with levothyroxine （L-T4）, while the control group was only treated with L-T4. Both groups received treatment for three months. At the beginning of the treatment, detected concentrations of TG and TG-Ab in peripheral blood as well as safety indexes including liver and kidney function, and thyroid function. After treatment, determined concentrations of TG and TG-Ab in peripheral blood and safety indexes including free triiodothyronine（FT3）, free thyroxine（FT4）, aspartate transaminase（AST）, alanine aminotransferase （ALT）, and serum creatinine （SCr） again. The changes of concentrations of TG and TG-Ab were compared after treatment. Results= After treatment, respectively compared the differences of TG-Ab in peripheral blood in the observation group with those in the control group, differences were significant （P 〈0.01）. After treatment, compared the difference of TG in patients who received total resection in the observation group with those of the control group, the difference was significant （P 〈 0.01）. Respectively compared the difference of TG-Ab in patients who received subtotal resection and in those who received total resection in the observation group with those in the control group, differences were significant（P〈 0.01）. No significant difference was found in the comparisons of adverse reaction, liver and kidney function indexes such as ALT, AST and SCr, and thyroid function indexes such as T4, T3, FT4, and FT3 between the two groups before and after treatment（P〉 0.05）. After treatment, compared ALT, AST, SCr, T4, Ta, FT4, and FT3 between the two groups, there was no significance being found in differences （P〉 0.05）, suggesting both therapies had certain safety. Conclusion.. Compound Chinese medicine therapy for postoperative differentiated thyroid carcinoma patients can improve serum TG as well as TG-Ab, and it has certain safety.
出处
《新中医》
CAS
2017年第11期95-98,共4页
New Chinese Medicine
基金
浙江省名中医专家传承工作室项目(GZS20120031)
关键词
分化型甲状腺癌术后
中医疗法
甲状腺球蛋白
甲状腺球蛋白抗体
Postoperative differentiated thyroid carcinoma
Chinese medicine therapy
Thyroglobulin （TG）
Thyroglobulinantibody （TG-Ab）
