摘要
目的:基于单中心临床数据选取糖尿病患者的用药信息,针对联合使用丹红注射液的用药规律进行数据挖掘,为后续开展丹红注射液与降糖药物相互作用实验研究提供临床依据。方法:选取南京中医药大学附属医院HIS数据库中2013年1月-2015年12月使用丹红注射液的2 206例糖尿病患者的医嘱信息,运用基本统计和关联分析方法分析丹红注射液与治疗糖尿病及其并发症相关药物的联合用药规律,并针对其与联用频数前3组降糖药物组合进行药物相互作用文献研究。结果:与丹红注射液联用的治疗糖尿病及其并发症的药物中,频数最高者依次为阿卡波糖、胰岛素类药物和二甲双胍。通过文献检索发现丹红注射液与这些药物联合用药相互作用研究的文献较少,且不够系统深入。结论:丹红注射液作为有效增益于糖尿病及相关并发症的辅助治疗药物,与降糖药物临床联合用药几率较高,但缺乏相关的药物相互作用研究,值得进一步系统探究。
OBJECTIVE To analyze the rules of drug combinations with Danhong injection based on clinical data of diabetic patients in the single medical center, provide the evidence for further researches on Danhong injection combined with other drugs for diabetes mellitus. METHODS Medical orders of 2 206 cases of diabetic patients were selected from Hospital Information System database of the affiliated hospital of Nanjing University of Chinese Medicine from January 2013 to December 2015. Frequency analysis and association rules analysis were chosen to investigate the common combination rules of Danhong injection and the medicine for diabetes and its complications. According to the statistics, we conducted a literature review of the drug-drug interactions of the top 3 combinations. RESULTS Acarbose, insulins and metformin were the most frequently combined medicines with Danhong injection to treat diabetes and its complications. It was found that there were few systematic references of the drug-drug interactions between Danhong injection and the agents mentioned above. CONCLUSION Danhong injection is confirmed to be commonly combined with hypoglycemic agents, as the effective assistant medicine for the treatment of diabetes mellitus and related complications. Furthermore systematic investigations of herb-drug interactions need to be proposed due to the lack of relevant researches at present.
出处
《中国医院药学杂志》
CAS
北大核心
2017年第21期2201-2205,共5页
Chinese Journal of Hospital Pharmacy
基金
国家"重大新药创制"科技重大专项(编号:2015ZX09501004001006)
江苏省中药资源产业化过程协同创新中心重点项目(编号:ZDXM-2-2)
江苏省高校自然科学研究重大项目(编号:14KJA360001)
江苏省高等学校大学生创新创业训练计划省级项目(编号:201510315064Y)
