摘要
目的分析妊娠中、晚期血清甲状腺功能参考值的范围。方法将2016年2月~2017年2月来我院接受孕期检查的500例妊娠女性作为研究组,其中300例为妊娠中期,200例为妊娠晚期,选择同期健康非妊娠育龄女性200例作为对照组。选择化学发光免疫法测定研究对象的游离甲状腺素(FT_4)、促甲状腺激素(TSH)、促甲状腺激素受体抗体(TRAb)、抗甲状腺球蛋白抗体(TgAb)以及抗甲状腺过氧化物酶抗体(TPOAb)水平,选择美国临床生化研究院(NACB)推荐的方法对我院妊娠中、晚期血清TSH和FT_4的范围进行初步检测。结果妊娠中、晚期的血清FT_4分布情况分别为9.79~17.29、9.53~16.85 pmol/L;妊娠中、晚期的血清TSH分布情况分别为0.64~5.33、0.61~5.62 m IU/L。将以上值作为判断标准,全部500例孕妇中,甲状腺疾病的发生率为7.2%(36/500)。结论制定妊娠各期血清甲状腺激素水平的正常范围,能为诊断和治疗妊娠期甲状腺疾病提供科学依据。
Objective To analyze the range of reference value of serum thyroid function in middle and late pregnancy. Methods 500 cases of pregnant women who received pregnancy check in our hospital from February 2016 to February 2017 were enrolled as the study group,among them,it included 300 cases of middle pregnancy women and 200 cases of late pregnancy women.Another 200 cases of healthy non-pregnant women of childbearing age were enrolled as the con- trol group.The serum level of free thyroxine （FT4）,thyroid stimulating hormone （TSH）,thyrotropin receptor antibody （TRAb）,anti-thyroglobulin antibody （TgAb） and anti-thyroid peroxidase antibody （TPOAb） of the subjects were detected by chemiluminescence immunoassay,the reference value of FT4 and TSH in middle and late pregnancy were initially tested by methods which recommended by American Institute of Clinical Biochemistry （NACB）.Results The distribution situation of serum FT4 was ranged from 9.79 to 17.29 pmol/L and 9.53 to 16.85 pmol/L in middle and late pregnancy respectively.The distribution situation of serum TSH was ranged from 0.64 to 5.33 mIU/L and 0.61 to 5.62 mIU/L in middle and late pregnancy respectively.The incidence rate of thyroid disease was 7.2% （36/500） when the above refer- ence was used as the judgment criterion.Conclusion Establishing the normal range of serum thyroid hormone level in different stages of pregnancy can provide a scientific basis for the diagnosis and treatment of thyroid disease during pregnancy.
出处
《中国当代医药》
2017年第31期103-105,共3页
China Modern Medicine
基金
江西省南昌市指导性科技计划项目(洪科字[2016]96号第25项)
关键词
妊娠
血清
甲状腺功能
参考值
Pregnancy
Serum
Thyroid function
Reference value
