摘要
目的探讨甲强龙联合常规治疗小儿重症手足口病的效果及对肿瘤坏死因子-α(TNF-α)、白细胞介素1β(IL-1β)等炎症因子的影响。方法将2014年7月~2017年2月于我院治疗重症手足口病患儿90例纳入研究并依据随机数字表法分组,每组45例。对照组采用常规治疗,观察组联合甲强龙,7 d为1个疗程。比较两组患者的炎症因子改善情况及临床疗效。结果观察组的口腔溃疡愈合时间、退热时间、食欲好转时间、皮疹消退时间短于对照组,差异有统计学意义(P<0.05);治疗7 d后,两组患者的血清肿瘤坏死因子(TNF-α)、白细胞介素1β(IL-1β)水平降低,差异有统计学意义(P<0.05);治疗后,观察组的血清TNF-α为(142.49±25.46)ng/L、IL-1β为(52.92±8.26)ng/ml,低于对照组的(173.65±27.89)ng/L、(69.85±17.31)ng/ml,差异有统计学意义(P<0.05)。观察组的总有效率为93.33%,高于对照组的77.78%(P<0.05)。结论甲强龙联合常规治疗小儿重症手足口病效果显著,可缩短病程,改善炎症反应,促进疾病康复,值得推广。
Objective To investigate the curative effect of Methylprednisolone combined with conventional treatment on severe hand foot mouth disease （I-IFMD） in children and its influence on inflammatory factors such as tumor necrosis factor-α （TNF-α）,interleukin 1β （IL-1β）.Methods 90 children with severe hand foot mouth disease from July 2014 to February 2017 treated in our hospital were selected and were divided according to the random number table method, and there were 45 cases in each group.The control group was given the conventional treatment,while the observation group was combined with Methylprednisolone.7 days was a course of treatment.The improvement of inflammatory factors and clinical efficacy were compared between the two groups.Results The oral ulcer healing time,fever disappearing time,appetite improvement time and rash extinction time of the observation group were shorter than those of the control group,and the difference was significant （P〈0.05）.After 7 days treatment,serum tumor necrosis factor （TNF-α）,interleukin 1β（IL-1β） in two groups were decreased,the difference was statistically significant （P〈0.05）.After treatment, TNF-α and IL-1β in observation group was （142.49±25.46） ng/L and （52.92±8.26） ng/ml respectively,which was lower that of the control group [（173.65±27.89） ng/L,（69.85±17.31） ng/ml] respectively,and the difference was significant （P〈0.05）.The total effective rate in the observation group was 93.33%,which was higher than that of the control group （77.78%） （P〈0.05）.Conclusion Methylprednisolone combined with conventional treatment treating severe hand foot mouth disease in children with has a remarkable effect,which can shorten the course of disease,improve inflammatory response,and promote disease recovery,and it is worthy of promotion.
出处
《中国当代医药》
2017年第31期109-111,共3页
China Modern Medicine
关键词
甲强龙
小儿重症手足口病
炎症因子
症状体征
Methylprednisolone
Severe hand foot mouth disease in children
Inflammatory factors
Symptom and sign
