摘要
机械力刺激能够诱发机体中包括牙周组织在内的多种组织发生无菌性炎症反应,并能促进免疫细胞以及一些非免疫细胞如牙周膜细胞发生焦亡(pyroptosis)。现有研究表明,Gasdermin-D(GSDMD)在炎症反应、细胞焦亡发生中具有重要作用,但GSDMD是否参与机械力刺激引发的炎症反应和细胞焦亡尚未可知。综述机械力刺激诱导机体组织炎症反应以及焦亡的信号通路研究进展。
Mechanical forces can induce aseptic inflammatory reactions in human tissues including periodontium, and promote the pyroptosis of immune cells and some non-immune cells such as periodontal ligament cells. Re- cent studies have revealed that Gasdermin-D （GSDMD） plays an indispensable role in inflammation as well as pyroptosis, while it remains unknown whether GSDMD participates in the mechanical force-induced inflammatory reaction and pyroptosis. The current progress in researches about the mechanical force-induced inflammatory re- action and the signaling pathways of pyroptosis in human tissues is reviewed.
出处
《医用生物力学》
EI
CAS
CSCD
北大核心
2017年第5期476-480,共5页
Journal of Medical Biomechanics
基金
国家自然科学基金项目(31470903
31270991
30900282)
上海市浦江人才计划项目(13PJD021)
上海市青年科技启明星计划(A类)项目(10QA1404200)
上海高校高峰高原学科建设项目
上海市重点学科建设项目(T0202
S30206-sms 02)
关键词
机械力
刺激
炎症
细胞焦亡
Mechanical force
Stimulation
Inflammation
Cell pyroptosis
