摘要
目的探讨青藏高原藏族人群Graves病(GD)与细胞毒性T淋巴细胞相关抗原(CTLA-4)基因多态性及炎症因子的相关性。方法以96例世居于海拔3 000米以上的GD患者为研究对象纳入观察组,选择同期90例世居于海拔3 000米以上的健康体检者纳入对照组A,90例世居于海拔2 200米健康体检者纳入对照组B,对三组对受试者CTLA-4基因多态性及血清肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)水平与三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)水平的相关性进行观察。结果观察组CTLA-4基因1+49 A/G位点G/G基因型频率及G等位基因频率高于对照组A及B,A/A基因型频率及A等位基因频率明显低于对照组A和对照组B(P<0.05);IL-6及TNF-α水平均与FT_3、FT_4呈正相关(P<0.05)。结论CTLA-4外显子1+49位点的多态性可能与青海藏族GD患者疾病的发生存在一定相关,炎性因子水平检测可能对GD病情的诊断及治疗效果的判断有一定指导意义。
Objective To observe the correlative relationship between Graves disease(GD)and CTLA-4 gene polymorphism and inflammatory factors in Tibetan population of Qinghai-Tibet plateau.Methods The study group:96 cases of GD patients over 3 000 meters above sea level over3 000 meters above sea level;The control group A:90 cases of high altitude Tibetan health volunteers on 2 200 meters above sea level;The control group B:90 cases of low altitude healthy volunteers.Three groups of CTLA-4 gene polymorphisms and the correlation between TNF-αand IL-6 levels and FT_3and FT_4 levels were observed.Results The frequencies of G/G genotype and G allele of CTLA-4 gene 1+49 in observation group were significantly higher than control group A and B,A/A genotype frequency and A allele frequency were significantly lower than the control group A and B(P<0.05);IL-6 and TNF-αlevels were positively correlated with FT_3 and FT_4(P<0.05).Conclusion Polymorphism of exon 1+49 locus of CTLA-4 may be related to the occurrence of disease in Qinghai Tibetan GD patients,the detection of inflammatory factor may be helpful in the diagnosis and treatment of GD disease.
出处
《中国继续医学教育》
2017年第25期32-34,共3页
China Continuing Medical Education
