摘要
目的分析头孢菌素类抗生素药物的安全性。方法回顾性分析南华大学第二附属医院2016年1—7月收治的接受头孢菌素类抗生素治疗的住院患者1850例,根据患者有无发生不良反应分为正常组(未发生不良反应)1480例和反应组(发生不良反应)370例,比较两组患者年龄、性别、联合用药情况、给药方式,观察反应组不良反应发生情况,并分析发生不良反应药物所涉及的药品种类和所累积器官系统情况。结果 1850例患者中出现药物不良反应370例,不良反应发生率为20.0%。两组患者年龄、联合用药、吸烟史、不合理用药及给药方式比较,差异有统计学意义(P<0.05)。反应组中所涉及的药物中以头孢哌酮占比最高,不良反应症状主要累及皮肤及其附件。结论头孢菌素类抗生素所致的不良反应发生率较高,在临床应用时应加强对抗生素类药物的监测,避免或减少药物不良反应的发生。
Objective To investigate the safety of spore formation antibiotics. Methods A total of 1850 cases of inpatients were retrospective analysed from January to July 2016 in the Second Affiliated Hospital of Nanhua University,which were divided into normal group（ n = 1480） and response group（ n = 370） according to adverse reactions. The ages,genders,combined drug usage,administration methods were compared between the two groups,and the incidence of adverse reactions were observed,and the types of drugs involved in the adverse drug reactions and the accumulated organ systems were analysed.Results In 1850 cases of patients,drug adverse reaction was for 20. 0%. There were significant differences of ages,combined drug usage,irrational drug use,administration methods between the two groups（ P 〈 0. 05）. In response group,the adverse reactions caused by drugs in the highest proportion was for cefoperazone,and the adverse reactions mainly involved the skin and its annex. Conclusion The incidence of adverse reactions caused by cephalosporin antibiotics is highest,so the monitoring of antibiotics should be strengthened to avoid and reduce the occurrence of adverse drug reactions in clinical application.
出处
《临床合理用药杂志》
2017年第30期97-98,共2页
Chinese Journal of Clinical Rational Drug Use
