摘要
稳定同位素分析揭示古代（现代）人群的食物结构，其原理为＂我即我食＂，即人体组织的稳定同位素比值，与其消化吸收转化而来的食物组分，存在着一一对应关系。然而，当人体代谢发生异常时，这种对应关系将被打破，产生＂我非我食＂现象。目前，探究＂我非我食＂与古代（现代）人体的健康之联系，已成为生物医学和生物考古界的研究热点。颇为遗憾的是，迄今为止，我国尚无学者对此有所关注。为此，本文以中国北方地区2名代谢性异常患者（直肠癌为例）头发样本为研究对象，通过对人发系列的C、N稳定同位素分析，追踪癌症患者头发同位素值的变化趋势，探讨其生理病理因素与稳定同位素之间的内在关系。研究结果显示：人发C、N同位素比值的变化，与其健康状况密切相关。在直肠癌发病初期，患者的δ13C与δ15N值均呈现出上升趋势，这可能是癌细胞代谢活跃、更多地利用机体中的14N和12C所致，或者与癌细胞具有未知的、独特的代谢途径相关。最后，详细阐述了＂我即我食＂和＂我非我食＂的区别和联系，并对如何在我国开展此领域的研究进行了展望。
The principle of stable isotope analysis to reveal the diets of ancient or modern humans is ＂You are what you eat＂. In other words, the stable isotope values of human tissues correspond directly to those of the foods consumed after the process of digestion, absorption and transformation. However, when human metabolic abnormality happens, the isotopic correspondence between the tissues and foods will be broken and the phenomenon, i.e., ＂You are not what you eat＂, will occur. Currently, the exploration of the relationship between ＂you are not what you eat＂ and the health of ancient or modern humans has become one of the research hotspots in the biomedical and bioarchaeological fields. It is a great pity that there has not been any research undertaken in China yet. Thus, in this study, stable isotope analysis （C, N）of a series of hair from two patients with metabolic abnormality （rectal cancer）in Northern China was carried on. All samples were cut from the scalp of hairs. The diets of the two patients are similar and they rely on wheat-made foods with less meat, seafood and dairy products based on the inquiry investigation. The aim of the study is to track the trends of isotopic variations during the process of hair growth and explore the inner correlation between stable isotope values and human physiological and pathological factors. The results indicate that the isotopic variations of human hair are highly related to human health. With the development of disease, patients receiving medical treatment and suffering from nutritional stress, the carbon and nitrogen isotope values change subsequently. During the initial stage of rectal cancer, both the δ13C and δ15N values rise. This pattern might be caused by more utilization of 14N and 12C of cancer cells given their abnormally metabolic rates, or unknown and unique metabolic pathways of cancer cells. The onset time of rectal cancer has close relationship with the alterations of δ13C and δ15N values. This is essential to explore the causes and the special metabolism pathways of rectal cancer. At last, the distinction and connection of ＂You are what you eat＂ and ＂You are not what you eat＂ was discussed and how to undertake this research was forecast.
出处
《第四纪研究》
CAS
CSCD
北大核心
2017年第6期1464-1471,共8页
Quaternary Sciences
基金
国家自然科学基金项目（批准号：41373018）、国家重点基础研究发展规划项目（批准号：2015CB953803）、国家自然科学外籍青年科学家项目（批准号：41550110224）、中国科学院国际访问学者项目（批准号：2016VBC002）和教育部人文社会科学研究青年基金（批准号：15YJCZH132）共同资助
关键词
我即我食
我非我食新陈代谢异常
C、N稳定同位素
直肠癌
you are what you eat, you are not what you eat, metabolism abnormality, stable carbon andnitrogen isotope, rectal cancer
