摘要
目的 评价先天性心脏病伴不同程度肺动脉高压（PAH）患儿手术前后不同时间血浆脑钠肽（BNP）的变化.方法 纳入2013年12月至2014年12月内蒙古医科大学附属医院经超声心动图确诊的左向右分流先天性心脏病患儿60例,采用超声心动图评估肺动脉收缩压,比较不同程度PAH患儿手术前后不同时间血浆BNP水平差异.结果 术前及术后7d血浆BNP水平均随PAH严重程度增高而升高,其中术前及术后7d血浆BNP水平在无PAH,轻度、中度、重度PAH患儿间差异均有统计学意义[术前血浆BNP水平四组分别为（38.74±6.42）pg/ml、（134.36±22.40）pg/rnl、（307.46±86.06）pg/ml、（661.12±66.88）pg/ml;术后血浆BNP水平四组分别为（188.62±18.07）pg/ml、（253.78 ±26.00）pg/ml、（553.33±31.02）pg/ml、（789.63±108.97）pg/ml,P＜0.05];而在术前及术后7d除重度肺动脉高压组未见统计学差异,其余三组间均有统计学意义.结论 左向右分流先天性心脏病患儿手术前后血浆BNP水平随PAH严重程度的增高而逐渐升高,可作为评价PAH程度的一项指标,有助于保障患儿的健康,值得在实际中应用.
Objective To study the perioperation change of plasma brain natriuretic peptide （BNP） in children with congenital heart disease combined pulmonary hypertension.Methods 60 cases with left to right shunt congenital heart admitted in Inner Mongolia medical university affiliated hospital from December 2013 to December 2014 were enrolled.The pulmonary artery systolic pressure was evaluated by the echocardiography,and the different degree PAH plasma,BNP levels before and after surgery were compared.Results The blood plasma BNP levels in preoperative and seventh day of postoperative were rised with the increasing severity of PAH,and there were statistical significance among the absence of PAH,mild,moderate and severe PAH patients （P〈0.05）.In preoperative and postoperative 7th day,the level of BNP was no statistical significance in the severe pulmonary hypertension group,but in the other three groups there were statistical significance （P〉0.05）.Conclusion The level of plasma BNP increases with increasing of PAH in children with congenital heart disease combined pulmonary hypertension,and may be used as an evaluation of the degree of PAH.
出处
《中国心血管病研究》
CAS
2017年第9期829-832,共4页
Chinese Journal of Cardiovascular Research
关键词
脑钠肽
先天性心脏病
肺动脉高压
临床意义
Brain natriuretic peptide
Congenital heart disease
Pulmonary arterial hypertension
Clinical significance
