摘要
目的:了解马鞍山市人民医院(以下简称"该院")抗菌药物致药品不良反应(adverse drug reaction,ADR)发生情况,为临床合理应用抗菌药物提供参考。方法:回顾性分析该院270例抗菌药物致ADR患者的性别与年龄、给药途径、涉及的抗菌药物种类、累及器官和(或)系统及临床表现、ADR关联性评价、级别分布及转归。结果:270例ADR报告中,男性患者略多于女性;年龄11~94岁,≥60岁者较多;给药途径主要为静脉滴注(267例,占98.89%)。共涉及抗菌药物9类27种,引发ADR病例数排序居前3位的分别为头孢菌素类抗菌药物、氟喹诺酮类抗菌药物和其他β-内酰胺类+β-内酰胺酶抑制剂复方制剂;引发ADR病例数排序居前3位的具体药品为左氧氟沙星、头孢呋辛和头孢哌酮舒巴坦。270例ADR主要累及皮肤及其附件(140例,占51.86%),其次为消化系统(85例,占31.48%);评价为"很可能"有关249例(占92.22%),"可能"有关21例(占7.78%)。新的、一般的ADR和严重的ADR共49例(占18.15%);所有患者经停药及对症治疗后治愈或好转,未见病情加重、死亡或后遗症病例。结论:抗菌药物致ADR的发生与多种因素相关,医疗机构应加强对抗菌药物的应用管理,加大对ADR的监测力度,规范临床用药行为,促进合理用药。
OBJECTIVE：To investigate the incidence of adverse drug reactions （ ADR） induced by antibiotics in the People ＇ s Hospital of Maanshan （ hereinafter referred to as ＂this hospital ） , and provide references for the clinical rational application of antibiotics .METHODS：Retrospective analysis was conducted on 270 cases of antibiotics inducing ADR in terms of patients ＇ genders and ages , administration routes , species of involved antibiotics , involved organs and （ or ） systems and its clinical features , relevance evaluation on ADR , distribution of ADR levels and prognoses.RESULTS：Among the 270 reports, the number of male patients was slightly more than females;aged from 11 to 94, most patients aged ≥60;the main administration route was intravenous drip （267 cases, 98.89%）.Totally 27 species of 9 class of antibiotics were involved , the top 3 were respectively cephalosporins , fluoroquinolones , other compound preparation of β-lactams and β-lactamases inhibitors; the top 3 specific drugs inducing ADR were respectively levofloxacin , cefuroxime and cefperazone-sulbactam .The 270 cases of ADR were mainly involving skin and its accessories （ 140 cases, 51.86%）; secondly was digestive system （ 85 cases, 31.48%）; relevance evaluations on 249 cases were ＂quite possible＂ （92.22%）, 21 cases were ＂possible＂ （7.78%）.49 cases of ADR （ 18.15%） were new , general and severe; all patients were cured or went better after drug withdrawal and symptomatic treatment , no aggravation , death or sequela were found .CONCLUSIONS：The antibiotics inducing ADR are multi-factors related , application management on antibiotics and monitoring on ADR need to be reinforced , and clinical medication needs to be standardized , so as to promote clinical rational medication .
出处
《中国医院用药评价与分析》
2017年第10期1413-1415,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
抗菌药物
药品不良反应
合理用药
Antibiotic
Adverse drug reaction
Rational medication
