摘要
目的研究桥本甲状腺炎(HT)合并甲状腺癌(PTC)的临床表现,并进行病理分析。方法选取温州医科大学附属第三医院收治的HT合并PTC患者30例为观察组,另外选择同期收治的单纯HT患者70例为对照组,采用酪氨酸激酶受体(RET)免疫组化法进行染色,对两组临床表现及病理进行分析。结果两组患者的临床表现有一定的相似性,包括胸闷、气短、声嘶、颈部压迫感和不适感。其中观察组患者颈部压迫感14例,颈部不适感7例,胸闷及气短4例,声嘶3例,甲状腺功能减退症2例。对照组患者颈部压迫感31例,颈部不适感18例,胸闷及气短12例,声嘶6例,甲状腺功能减退症3例。HT合并PTC患者病理的组织形态分布最常见的为淋巴细胞浸润、癌细胞胞质嗜酸性、纤维化。对照组患者病理组织形态多表现为多样化特点,大部分为结节状。观察组主要为乳头状癌,且观察组RET阳性率高于对照组,差异有统计学意义(P<0.01)。结论 HT与PTC的临床症状和病理基础具有一定的相似性,其中HT是引发患者发生PTC的重要病因,对HT患者积极的治疗,可有效防止疾病的恶化,临床应当予以重视。
Objective To investigate the clinical manifestations and pathological analysis of Hashimoto's thyroiditis( HT) with thyroid carcinoma( PTC). Methods A total of 30 patients HT with PTC in the Third Affiliated Hospital of Wenzhou Medical University were selected as the observation group,another choice during the same period were simply HT patients 70 cases as control group,using tyrosine kinase receptor immunohistochemistry( RET) staining analysis,histopathological analysis and clinical manifestations of the two groups. Results The patients of two groups have certain similarity, including chest tightness,shortness of breath,hoarseness,neck stress and discomfort. In observation group of patients,14 cases with neck oppressive feeling,7 cases with neck discomfort,4 cases with chest tightness,shortness of breath,3 cases with hoarseness,2 cases with hypothyroidism. In Control group of patients 31 cases with neck and oppressive feeling,18 cases with neck discomfort,12 cases with chest tightness and shortness of breath,6 cases with hoarseness,3 cases with hypothyroidism. Combined PTC patients with pathological HT distribution of the most common form of lymphocytic infiltrates eosinophilic cytoplasm,fibrosis,and cancer cells. Control group patients with pathological organization form characterized by diversified characteristics, mostly nodular. Observation group mainly for papillary carcinoma, RET positive rate is higher than that in the control group, the difference was statistically significant( P < 0. 01). Conclusion The clinical symptoms and pathological basis of Hashimoto' s thyroiditis and thyroid cancer has a certain similarity,which is an important cause of Hashimoto's thyroiditis with thyroid cancer,for the treatment of Hashimoto's thyroiditis patients with positive and effective way can prevent the deterioration of disease,more attention should be paid to the clinical.
出处
《中国全科医学》
CAS
北大核心
2017年第A01期72-74,共3页
Chinese General Practice
