摘要
目的:探讨补中益气五苓汤联合卡维地洛治疗老年慢性心力衰竭(CHF)的临床疗效。方法:2014年6月~2016年1月,68例老年CHF患者随机分为对照组和观察组各34例。在CHF标准化治疗的基础上,对照组给予卡维地洛治疗,观察组给予补中益气五苓汤联合卡维地洛治疗,疗程均为12周。比较两组患者治疗前后的中医症候积分、6min步行试验(6MWT)距离和血浆N端脑钠肽(NT-ProBNP)水平、左射血分数(LVEF)、左室舒张末内径(LVEDD)和左心室收缩末期内径(LVESD)等指标的变化,观察两组患者治疗前后的临床症状和心功能改善情况以及不良反应发生情况,评估两组患者的临床疗效。结果:观察组患者治疗后的中医症候积分和血浆NT-ProBNP水平明显低于对照组,6MWT距离和LVEF明显高于对照组,LVEDD和LVESD明显低于对照组(P<0.05);观察组治疗总有效率为91.2%,明显高于对照组的70.6%(P<0.05)。两组患者不良反应发生率无明显差异(P>0.05)。结论:补中益气五苓汤联合卡维地洛治疗老年CHF,可有效改善患者的临床症状和心功能,提高运动耐量,且不良反应少,值得应用于临床。
Objective：To discuss the clinical effects of Buzhong Yiqi Wuling decoction combined with carvedilol in the patients with chornic heart failure. Methods：Totally 68 patients with chornic heart failure from June 2014 to January 2016 in our hospital were randomly selected and divided into the control group with 34 patients treated with carvedilol and the research group with the other 34 patients treated with Buzhong Yiqi Wuling decoction combined with carvedilol. The TCM symptom integral, distances of 6-minute walk-ing test, NT-ProBNP plasma levels, LVEF, LVEDD and LVESD before and after the treatment in the two groups were compared, and the clinical symptoms, cardiac function and adverse reactions in the two groups were observed to evaluate the clinical effects. Results：The TCM symptom integral and NT-ProBNP levels in the research group after the treatment were lower than those in the control group, and the distances of 6-minute walking test in the research group after the treatment was longer than that in the control group, the LVEF in the research group after the treatment was higher than that in the control group, the LVEDD and LVESD in the research group after the treatment were smaller than those in the control group, and all the differences were statistically significance（P〈0. 05）. The total effective rate was 91. 2% in the research group, which was higher than that in the control group （70. 6%）, and the difference was sta-tistically significance（P〈0. 05）. No difference in the incidence of adverse reactions was shown between the groups （P〉0. 05）. Con-clusion：Buzhong Yiqi Wuling decoction combined with carvedilol in the patients with chornic heart failure can improve the clinical symptoms, cardiac function and exercise tolerance with fewer adverse reactions, which is worthy of clinical use.
出处
《中国药师》
CAS
2017年第10期1792-1795,共4页
China Pharmacist
基金
海南省自然科学基金项目(编号:814347)
关键词
补中益气五苓汤
卡维地洛
慢性心力衰竭
临床疗效
Buzhong Yiqi Wuling decoction
Carvedilol
Chornic heart failure
Clinical effects
