摘要
目的:探究甲胎蛋白联合肿瘤标志物检测在原发性肝癌(PHC)患者临床诊断中的应用效果。方法:以某院2015年9月~2016年9月收治的140例原发性肝癌患者作为甲组,并选取同期在某院进行治疗的140例良性肝病患者以及接受健康体检的140例正常人分别作为乙组和丙组,分别对3组研究对象的血清甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原125(CA125)的水平采用电化学发光方法进行准确的检测,对其检测结果进行处理分析。结果:甲组血清中AFP、CEA、CA199以及CA125的检测结果均明显高于乙组和丙组,且乙组以上各指标水平均明显高于丙组,差异显著具有统计学意义(P<0.05);AFP、CEA、CA199以及CA125四项联合检查的敏感性以及准确性均明显高于单项检查结果,但是其特异性却明显低于单项检查,差异显著具有统计学意义(P<0.05)。结果:将甲胎蛋白联合肿瘤标志物检测能够有效的提高原发性肝癌检测的敏感性,可以有效的弥补单项检测所存在的不足。
Objective： To investigate the effect of alpha fetoprotein combined with tumor markers detection in the diagnosis of primary liver cancer （PHC）. Methods： 140 cases with primary liver cancer in our hospital from September 2015 to September 2016 were regarded as the group A. Another 140 patients with benign liver cancer were the group B and the group C was made up of 140 normal subjects. Respectively, the rates of serum AFP subjects （AFP）, carcinoembryonic antigen （CEA）, carbohydrate antigen 199 （CA199）, carbohydrate antigen 125 （CA125） are tested by electrochemilumineseence for accurate detection, processing and analysis of the test results. Results. The serum AFP, CEA, CA199 and CA125 in the group A were sig- nificantly higher than those in group B and group C and each index in group B was significantly higher than that in group C. And the difference was statistically significant （P〈0.05）.The joint inspection sensitivity and accuracy of AFP, CEA, CA199 were higher than that of the single examination results, but the specificity was significantly lower than that in single examination, with significant difference （P〈0.05）. Conclusion. The detection of alpha fetoprotein combined with tumor markers can effectively improve the sensitivity of the detection of primary liver cancer, and it can effectively make up for the shortcomings of single detection.
出处
《数理医药学杂志》
2017年第12期1755-1757,共3页
Journal of Mathematical Medicine
关键词
甲胎蛋白
肿瘤标志物
原发性肝癌
alpha fetoprotein
tumor marker
primary liver cancer
