摘要
目的:探讨妊娠早期合并甲状腺功能异常对分娩并发症发生的影响。方法:选取2014年2月到2016年3月广州市妇女儿童医疗中心150例产妇作为研究对象,其中75例甲状腺功能异常者作为观察组,75例甲状腺功能正常者作为对照组。对比两组产妇并发症的发生情况,并检测TSH、FT4、TPOAb。结果:观察组妊娠早期、妊娠中期、分娩时、脐带血TSH、FT4、TPOAb水平与对照组比较,差异有统计学意义(均P<0.05)。观察组流产患者占比高于对照组,新生儿体质量低于对照组(均P<0.05)。观察组早产、妊娠期高血压、妊娠期糖尿病者占比均高于对照组(均P<0.05)。结论:妊娠早期合并甲状腺功能异常产妇若不能得到有效的治疗,流产、妊娠期糖尿病以及妊娠期高血压疾病发生几率高于甲状腺正常产妇,应及时发现并给予相应的治疗,减少产科并发症发生。
Objective： To investigate the impacts of thyroid dysfunction in early pregnancy on the occurrence of obstetric complications. Methods： Included in this study were 150 pregnant women registered to Guangzhou Women and Children＇ s Medical Center between January 2014 and March 2016. Seventy cases with thyroid dysfunction was recruited as the study group, and 75 with normal thyroid function as the control group. The two groups were compared for occurrence of obstetric complications, and levels of TSH, FT4, and TPOAb. Results ： Compared with the controls, there were significant differences in TSH, FT4 and TPOAb during the first and second trimesters,at delivery and in the cord blood （all P〈0.05）. Women in the study group were more likely to have miscarriage or babies with a lower birthweight compared with those in the control group （both P〈0.05）. The incidence of preterm delivery, gestational hypertension or diabetes was significantly more common in the study group than in the control group （all P〈 0.05 ）. Conclusion： RWomen with thyroid dysfunction during early pregnancy, if not properly treated, would show higher likelihoods for miscarriage, gestational hypertension or diabetes than those with normal thyroid function. Early identification and timely management should be expected to reduce the occurrence of obstetric complications.
出处
《广州医科大学学报》
2017年第1期16-19,共4页
Academic Journal of Guangzhou Medical University
基金
广州市卫生和计划生育委员会2017年度一般引导项目(穗卫科教[2017]6号)
关键词
妊娠早期
甲状腺功能障碍
产科并发症
early pregnancy
thyroid dysfunction
obstetric complications
