摘要
目的研究中药人工周期联合地屈孕酮片对宫内膜异位症(EMs)不孕患者妊娠及血清学的影响。方法选取2014年3月至2016年3月间在南通市中医院接受治疗的EMs不孕患者96例,依据随机数表法将患者分成两组:对照组(48例)使用地屈孕酮片治疗,观察组(48例)在对照组基础上结合中药治疗;观察患者治疗后妊娠情况、治疗前后血清肿瘤坏死因子-α(TNF-α)、白介素6(IL-6)水平变化情况,使用B超检测患者A型子宫内膜数量,卵泡发育状况,子宫内膜的厚度和排卵日内卵巢血流动力学情况。结果观察组和对照组患者妊娠率分别为54.17%、37.50%,差异有统计学意义(P<0.05);治疗后观察组和对照组患者血清TNF-α[(17.45±4.26)ng/m L vs(22.07±4.36)ng/m L]、IL-6[(18.24±3.16)pg/m L vs(23.17±3.50)pg/m L]、舒张期末流速(EDV)[(11.02±1.43)cm/s vs(9.30±1.86)cm/s]、搏动指数(PI)[(0.69±0.31)vs(1.21±1.05)]、收缩期峰值流速(PSV)[(21.10±1.89)cm/s vs(18.24±1.93)cm/s]比较,差异均有统计学意义(P<0.05)。结论中药人工周期联合地屈孕酮片可改善患者卵泡和子宫内膜的发育与生长,降低炎症因子水平,提高妊娠率。
Objective To study the pregnancy and serological effects of Chinese herbal medicine artificial cycle combined with dydrogesterone tablets in infertile patients with endometriosis （EMs）. Methods From March 2014 to March 2016, 96 EMs patients with infertility who admitted Nantong Hospital of Traditional Chinese Medicine were select-ed and divided into the observation group and the control group according to the random number table method, with 48 cas-es in each group. The control group was treated with dydrogesterone tablets, and the observation group received the com-bined treatment of traditional Chinese medicine and dydrogesterone tablets. The changes of serum tumor necrosis factor al-pha （TNF-α）, interleukin 6 （IL-6） levels before and after treatment and the post-treatment pregnancy were observed. Type A endometrial volume, follicle development status, dynamics of ovarian blood flow and endometrial thickness in ovulation in patients were checked by ultrasound. Results The pregnancy rate was 54.17%in the observation group versus 37.50%in the control group （P〈0.05）. The serum TNF-α, IL-6, end-diastolic velocity （EDV）, pulsatility index （PI）, peak systolic velocity （PSV） in the abservation group were respectively （17.45±4.26） ng/mL, （18.24±3.16） pg/mL, （11.02±1.43） cm/s, （0.69 ± 0.31）, （21.10 ± 1.89） cm/s versus corresponding （22.07 ± 4.36） ng/mL, （23.17 ± 3.50） pg/mL, （9.30 ± 1.86） cm/s, （1.21±1.05）, （18.24±1.93） cm/s in the control group （P〈0.05）. Conclusion Dydrogesterone tablets combined with Chi-nese medicine artificial cycle can improve the development and growth of follicles and endometrium, reduce the level of inflammatory factors, and increase the rate of pregnancy.
出处
《海南医学》
CAS
2017年第20期3318-3321,共4页
Hainan Medical Journal
基金
中国中医科学院江苏分院科研项目(编号:JSBN1309)
关键词
地屈孕酮片
中药人工周期
子宫内膜异位症
不孕
Dydrogesterone tablets
Traditional Chinese medicine artificial cycle
Infertility
