摘要
目的探讨痰热清注射液对心力衰竭伴肺部感染患者血清胆碱酯酶及免疫功能的影响。方法选取2013年3月-2015年8月医院符合标准的心力衰竭伴肺部感染患者90例,按随机数字表法分为2组,每组45例,对照组患者采用头孢哌酮/舒巴坦治疗,研究组在此基础上采用痰热清注射液治疗,持续1周,治疗前和治疗1周后采肘静脉血测定T淋巴细胞亚群(CD_8^+、CD_4^+/CD_8^+)、免疫球蛋白(IgG、IgM)和CHE、BNP、NT-proBNP等,测定心功能指标,同时比较临床疗效及不良反应。结果对照组总有效率为77.78%低于研究组的93.33%,差异有统计学意义(P<0.05);与治疗前比较,两组治疗1周后T淋巴细胞亚群(CD_8^+、CD_4^+/CD_8^+)和免疫球蛋白(IgG、IgM)升高,CHE升高,BNP、NT-proBNP降低,LAD、LVEDD、LVESD降低,LVEF升高(P<0.05);与对照组比较,研究组治疗1周后T淋巴细胞亚群(CD_8^+、CD_4^+/CD_8^+)和免疫球蛋白(IgG、IgM)较高,CHE较高,BNP、NT-proBNP较低,CHE较高,LAD、LVEDD、LVESD较低,LVEF较高(P<0.05);两组不良反应发生率比较,差异无统计学意义。结论痰热清注射液治疗心力衰竭伴肺部感染,有利于提高免疫功能和心功能,降低心肌损伤,且对肝/肾无影响,可作为临床治疗方案推广。
OBJECTIVE To explore the influence of Tanreqing injection on serum cholinesterase and immune func-tion of heart failure patients complicated with pulmonary infections.METHODS From Mar 2013 to Aug 2015,a to-tal of 90 heart failure patients complicated with pulmonary infections who were eligible for criteria were enrolled in the study and randomly divided into two groups,with 45 cases in each group.The control group was treated with cefoperazone-sulbactam,while the study group was given additional Tanreqing injection on basis of cefoperazone-sulbactam for one week.The elbow vein blood specimens were collected before the treatment and after the treat-ment for 1 weeks so as to determine the T lymphocyte subsets（CD8＋、CD4＋ /CD8＋）,immunoglobulins（IgG、IgM）,CHE、BNP and NT-proBNP,the cardiac function indexes were measured,and the clinical curative effect and incidence of adverse reactions were observed and compared.RESULTS The total effective rate of the control group was 77.78%,significantly lower than 93.33% of the study group（P〈0.05）.The levels of CD8＋,CD4＋ /CD8＋,IgG,IgM,CHE and LVEF of the two groups of patients were significantly higher after the treatment for 1 week than before the treatment,while the levels of BNP,NT-proBNP,LAD,LVEDD and LVESD of the two groups of patients were significantly lower after the treatment for 1 week than before the treatment（P〈0.05）. The levels of CD8＋,CD4＋ /CD8＋,IgG,IgM,CHE and LVEF of the study group were significantly higher than those of the control group after the treatment for 1 week,while the levels of BNP,NT-proBNP,LAD,LVEDD and LVESD of the study group were significantly lower than those of the control group after the treatment for 1 week（P 〈 0.05）.There was no significant difference in the incidence of adverse reactions between the two groups.CONCLUSION Tanreqing injection may facilitate the improvement of immune function and cardiac function of the heart failure patients complicated with pulmonary infections and reduce the myocardial damage, without affecting the liver or kidney,and it is worthy to be promoted in the hospital.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第22期5087-5090,共4页
Chinese Journal of Nosocomiology
基金
江苏省卫生厅科研基金资助项目(P201520)
关键词
痰热清注射液
心力衰竭
肺部感染
胆碱酯酶
免疫功能
Tanreqing injection
Heart failure
Pulmonary infection
Cholinesterase
Immune function
