摘要
植物衍生的化合物在我国已被广泛应用于医学领域,它们被认为对人体是安全的。黄芩苷是从唇形科植物黄芩的根茎中提取分离出来的一种黄酮类化合物,具有显著的生物活性。许多含有黄芩苷的中药配方被广泛应用于疾病的治疗,在临床医学占有重要地位。心肌纤维化是大多数心脏疾病发展到终末期形成心脏重构的组织病理学特征,它可以破坏心脏结构、损害心脏功能,增加恶性心律失常和心源性猝死等不良心血管事件的风险,严重威胁人类健康。心肌纤维化由多方面的因素形成,包括炎症、凋亡、p38丝裂原活化蛋白激酶、基质金属蛋白酶及转化生长因子-β等。该文通过阐述黄芩苷与以上促纤维化因素的相互影响,说明黄芩苷对心肌纤维化的生物学作用。
In China,plant-derived compounds,which are considered safe for the human body,have been widely used in the medical field. Baicalin,a kind of flavonoids extracted from the rhizomes of Scutellaria baicalensis,possesses significant biological activity. Multiple traditional Chinese medicine formulations containing baicalin are widely used in the treatment of various diseases,and have a high position in clinical medicine. Myocardial fibrosis is the histopathological feature of cardiac remodeling formed in the end-stage of most heart diseases,and it can destroy the cardiac structure,damage the heart function,increase the risk of adverse cardiovascular events such as malignant arrhythmias and sudden cardiac death,thereby severely threatening human health. Myocardial fibrosis occurs due to a variety of factors including inflammation,apoptosis,p38 mitogen-activated protein kinase,matrix metalloproteinases and transforming growth factor-β. In this paper,the biological effects of baicalin on myocardial fibrosis are expounded through elucidating the interaction between baicalin and these pro-fibrosis factors.
出处
《新医学》
2017年第12期829-832,共4页
Journal of New Medicine
基金
国家自然科学基金面上项目(81270310)
哈尔滨市科技创新人才研究专项资金(杰出青年人才)(2016RAYBJ005)
黑龙江省教育厅海外学人重点项目(1252HQ013)
关键词
黄芩苷
转化生长因子-Β
心肌纤维化
Baicalin
Transforming growth factor-β
Myocardial fibrosis
