摘要
目的运用计算机配色技术实现对中药复方散剂如意金黄散安慰剂制备时颜色的快速模拟及客观评价,为中药复方安慰剂颜色的模拟提供一种新的方法和思路。方法以如意金黄散安慰剂的研制为例,运用计算机配色技术建立着色剂样品颜色参数(L、a*、b*)与相应质量分数的数学模型,通过数据拟合及牛顿迭代法实现对着色剂质量分数的求解;采用颜色综合评价指标(ΔE)为客观评价标准,对验证试验结果进行评价。结果色差仪测定模型药物如意金黄散的颜色参数L、a*、b*均值分别为68.302 5、4.079 5、34.484 0,计算机建模并求解出安慰剂模拟时柠檬黄、苋菜红、亮蓝3种着色剂应添加的质量分数分别为0.837 3%、0.045 8%、0.008 5%;制备3批如意金黄散安慰剂进行验证,验证样品与模型药物的颜色差异综合评价指标(ΔE)值为2.750 0±0.353 6,肉眼直观评价也显示与模型药物基本一致。结论计算机配色技术能够快速模拟中药复方如意金黄散安慰剂的颜色,可应用于中药复方安慰剂的颜色模拟。
Objective To study the color of Ruyi Jinhuang Powder（RJP） placebo by using computer color matching technology and achieve fast preparation of RJP placebo. This work provided a new method to simulate the color of Chinese medicine compound placebo. Methods Using the RJP placebo as an example, computer color matching technology was used to establish a mathematical model to correlate the placebo color parameter L, a^＊, b^＊ value and the colorant concentration. For a measured medicine compound color, the placebo colorant concentration can then be calculated from the model through data fitting and Newton iterative method. The model accuracy was validated using the color comprehensive evaluation index（ΔE）. Results The color parameter L, a^＊, b^＊ of RJP placebo was 68.302 5, 4.079 5, and 34.484 0. The mass fraction of lemon yellow, amaranth, and blue was 0.837 3%, 0.045 8%, and 0.008 5%. The ΔE value between RJP and its placebo was 2.750 0 ± 0.353 6, and there was no obvious visual difference between the medicine compound and its placebo. Conclusion Computer color matching technology can be used to simulate the color of RJP placebo, and can be widely used in the preparation of Chinese medicine placebo.
出处
《中草药》
CAS
CSCD
北大核心
2017年第22期4648-4654,共7页
Chinese Traditional and Herbal Drugs
基金
北京市科委课题资助(Z161100001816013)
关键词
中药复方
如意金黄散
安慰剂
计算机配色技术
颜色模拟
CIELab颜色系统
Chinese materia medica compound
Ruyi Jinhuang Powder
placebo
computer color matching technology
color simulation
CIELab color system
