摘要
目的:研究扩散加权成像表观扩散系数(ADC)值在诊断乳腺癌中的作用以及它与肿瘤体积和分子生物标志物(雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体2(c-erb B-2))的关联。材料与方法:经手术病理确诊的84例(53例乳腺癌,31例良性)乳腺病变的患者均接受1.5T常规DWI检查。记录所有病灶ER、PR、HER2的表达情况及ADC值。结果:恶性病变的平均ADC值((1.02±0.13)×10^(-3)mm^2/s)显著低于乳腺良性病变的ADC值((1.56±0.29)×10^(-3)mm^2/s)。ADC阈值为1.23×10^(-3)mm^2/s(灵敏度88.5%,特异性85.1%,曲线下面积0.91)以区分乳腺恶性和良性疾病。与ER+,PR+和非三阴性(n TN)癌症相比,具有ER-,PR-和三阴性(TN)状态的乳腺癌分别显示出较大的肿瘤体积,更高的ADC值。结论 :本研究表明ADC值可以提高DCEMRI的诊断特异性,并且可用于临床工作中的治疗管理。
Objective： To investigate the role of apparent diffusion coefficient（ADC） value in the diagnosis of breast cancer and its association with tumor volume and hormonal receptors（estrogen receptor（ER）, progesterone receptor（PR）, and human epi- dermal growth factor （HER2））. Materials and Methods： Fifty-three patients with pathology-proven breast cancer and 31 with benign pathology were detected by diffusion weighted imaging （DWI） on 1.5T MR. ADC value and tumor size were measured respectively. Results： Mean ADC of malignant lesions was significantly lower （（1.02±0.13）×10-3 mm2/s） compared to benign （（1.56±0.29）×10-3 mm2/s） lesions. A cutoff ADC value of 1.23×10-3 mmZ/s （sensitivity 88.5%, specificity 85.1%, area under the curve 0.91） was obtained to differentiate malignant from benign diseases. Breast cancers with ER＋, PR＋, and triple-negative （TN） status showed a significantly larger tumor volume compared to ER＋, PR＋, and non-triple-negative （nTN） cancers, respec- tively. Furthermore, TN tumors showed a significantly higher ADC compared to ER＋, PR＋, and nTN cancers. Conclusion： ADC may increase the diagnostic specificity of DCE-MRI and be useful for evaluating prognosis of the tumor and guiding clinical therapy.
出处
《中国临床医学影像杂志》
北大核心
2017年第11期785-788,共4页
Journal of China Clinic Medical Imaging
关键词
乳腺肿瘤
免疫组织化学
磁共振成像
Breast neoplasms
lmmunohistochemistry
Magnetic resonance imaging
