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Evaluation of the Ability to Apply Near-Infrared Spectroscopy on Direct Assay of Acyclovir in Tablets

Evaluation of the Ability to Apply Near-Infrared Spectroscopy on Direct Assay of Acyclovir in Tablets
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摘要 This paper aimed at developing a simple and fast approach using chemometrics processing for direct assay of acyclovir in tablets by NIR (near infrared) spectroscopy in diffuse reflectance mode. In making trials with 5 different tablet matrices, the experimental results showed that regardless the matrix variation, it was always possible to construct a quantitative model with suitable linear range, accuracy and precision for direct assay of acyclovir in tablet from NIR spectra. Therefore, the approach used in this study was suitable for on-site fast assay of APIs in tablets during manufacturing process or in post-marketing surveillance of drug quality.
出处 《Journal of Pharmacy and Pharmacology》 2017年第12期841-849,共9页 药剂与药理学(英文版)
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