摘要
观察合并原发性甲状腺功能减退症的不孕症患者血清白细胞介素(IL)-8、IL-17和肿瘤坏死因子(TNF)-α的水平,探讨其与发病的相关性。选取合并甲减的不孕症患者32例,甲状腺功能正常的不孕症患者53例,30例体检正常育龄妇女作为对照。检测所有被检者血清IL-2、IL-17和TNF-α的水平。IL-2水平在甲功正常不孕组与对照组相似,但明显高于甲减不孕组(P<0.05);IL-17水平在对照组、甲功正常不孕组及甲减不孕组依次升高(P<0.01);TNF-α水平在甲减不孕组与甲功正常不孕组相似,但均高于对照组(P<0.01)。合并甲状腺功能减退症的不孕症患者血清IL-2水平降低,IL-17和TNF-α水平升高。IL-2可能仅参与了甲状腺功能减退的起病,而IL-17在不孕症和甲状腺功能减退起病中均起到重要作用。
To investigate the involvement of interleukin（ IL）-2,IL-17,and TNF-α in infertility with hypothyroidism. The baseline scram levels of IL-2,IL-17,and TNF-α were measured by ELISA. 32 infertility patients with hypothyroidism,53 infertility healthy patients with normal thyroid function,and 30 healthy subjects were selected to determine the associated changes of cytokines. Serum IL-2 levels were similar in infertility patients with normal thyroid function and healthy subjects compared with healthy subjects group,but higher compared with infertility patients with hypothyroidism group（ P〈0. 05）. Serum IL-17 level were gradually increased in infertility patients with hypothyroidism,infertility healthy patients with normal thyroid function,and 30 healthy subjects（ P〈0. 01）. Serum TNF-α were similar in infertility patients with hypothyroidism and with normal thyroid function,while higher compared with healthy subjects（ P〈0. 01）. The serum level of IL-2 was decreased in infertility patients with hypothyroidism,while the serum levels of IL-17 and TNF-α were increased. In addition,IL-17 might serve as a useful biomarker for evaluating infertility with Hypothyroidism.
出处
《安徽医科大学学报》
CAS
北大核心
2017年第12期1880-1882,共3页
Acta Universitatis Medicinalis Anhui
基金
安徽省高校省级自然科学研究项目(编号:KJ2013Z112)
安徽省自然科学基金(编号:1608085MH207)
