摘要
目的探究盐酸利托君联合硫酸镁在妊娠期糖尿病孕妇先兆早产中的应用效果。方法选取74例妊娠期糖尿病合并先兆早产患者为研究对象，根据随机数字表法将患者分成观察组和对照组各37例，对照组采用硫酸镁治疗，观察组采用硫酸镁联合盐酸利托君治疗。分别记录两组患者治疗期间和停药3d后空腹血糖水平和餐后2h血糖水平，孕期延长时间、并发症发生情况以及新生儿出生情况。结果观察组总有效率高达97．30％，显著高于对照组的83．78％，两组差异有统计学意义（M=2．336，P=0．019）。两组用药期间空腹血糖和餐后2h血糖水平较治疗前均上升，但两组差异均无统计学意义（t=1．904，P=0．060；t=1．698，P=0．093）；停药后，两组空腹血糖和餐后2h血糖均降低至治疗前水平，组间差异均无统计学意义（t=0．953，P=0．343；f=0．749，P=0．456）。观察组孕期平均延长（22．59±2．84）d，显著长于对照组（t=11．737，P=0．000）。观察组新生儿出生体质量和Apgar评分显著高于对照组（t=12．746，P=0．000；t=10．159，P=0．000）；观察组新生儿存活率97．30％，对照组新生儿存活率为93．78％，两组差异有统计学意义（x2=3．944，P=0．047）。结论盐酸利托君联合硫酸镁治疗妊娠期糖尿病合并先兆早产疗效较好，孕期延长．且并发症少。
Objective To explore the effect of ritodrine hydrochloride combined with magnesium sulfate in gestational diabetes mellitus pregnant women with threatened premature labor. Methods 74 gestational diabetes mellitus pregnant women with threatened premature labor were selected as the research subjects. According to the digital table ,they were randomly divided into observation group and control group ,37 cases in each group. The control group was treated with magnesium sulfate, the observation group was treated with ritodrine hydrochloride combined with magnesium sulfate. During treatment and after drug withdrawal 3 days, the fasting blood glucose levels and postprandial 2h blood glucose levels during pregnancy, prolonged time, complications and neonatal conditions in the two groups were recorded. Results The total effective rate of the observation group was 97. 30% , which was significantly higher than 83.78% of the control group, the difference was statistically significant between the two groups（ u = 2. 336 ,P = 0. 019 ）. The fasting blood glucose and 2h postprandial blood glucose levels were higher than before treatment in the two groups, but there were no statistically significant differences between the two groups （ t = 1. 904, P = 0.060 ; t = 1. 698, P = 0. 093 ）. After stopping the drug, the fasting blood glucose and 2h postprandial blood glucose of the two groups were reduced to the pre -treatment levels, but there were no statistically significant differences between the two groups （ t = 0. 953, P = 0. 343 ; t = 0. 749, P = 0. 456 ）. The average gestation duration prolonged time of the observation group was （22.59 ± 2.84） d, which was significantly longer than that of the control group（ t = 11. 737, P = 0.000）. The neonatal birth weight and Apgar score of the observation group were significantly higher than those of the control group（t = 12. 746,P =0.000;t = 10. 159,P =0. 000）. The neonatal survival rate of the observation group was 97.30% , which of the control group was 93.78%, the difference was statistically significant between the two groups （ X2 = 3. 944, P = 0. 047 ）. Conclusion Ritodrine hydrochloride combined with magnesiumsulfate in the treatment of gestationaI diabetes mellitus pregnant women with threatened premature labor has good resuhs,and can prolong pregnancy,and has less complications.
出处
《中国基层医药》
CAS
2017年第24期3681-3684,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省乐清市科技计划项目（Y2016Y005）
关键词
糖尿病
妊娠
流产
先兆
利托君
硫酸镁
Diabetes,gestational
Abortion,threatened
Ritodrine
Magnesimn sulfate
