摘要
目的探讨还少胶囊治疗少弱精子症的疗效。方法采用开放性、自身前后对照的临床研究方法,将193例少弱精子症患者随机分为3组。对照组60例给予口服维生素E片(1粒/次,3次/日),治疗组70例给予口服还少胶囊(3粒/次,3次/日),联合用药组63例给予口服还少胶囊(3粒/次,3次/日),同时加服维生素E片(1粒/次,3次/日)。3组均治疗12周。结果共有184例患者完成了临床研究,治疗4,8,12周后,治疗组和联合用药组的各项指标均有不同程度的改善,患者配偶受孕率明显提高;治疗12周后,精子密度治疗组增加了74.78%,联合用药组增加了83.48%;(a+b)级精子治疗组增加了98.74%,联合用药组增加了103.72%;a级精子治疗组增加了95.64%,联合用药组增加了94.97%;精子活率治疗组增加了72.26%,联合用药组增加了73.93%;精液量治疗组增加了30.99%,联合用药组增加了29.67%;精液液化时间治疗组降低了39.90%,联合用药组降低了39.41%;正常精子形态治疗组增加了160.80%,联合用药组增加了178.87%;精液中果糖含量治疗组、联合用药组分别增加了38.08%和40.90%;α-中性糖苷酶活性治疗组、联合用药组分别增加了41.75%和41.66%;治疗组和联合用药组的受孕率分别为19.70%和19.67%。结论还少胶囊可明显提高少弱精子症患者精液质量,提高患者配偶受孕率,未见明显不良反应。
Objective To investigate the clinical efficacy of Huanshao Capsules in the treatment of oligoasthenospermia. Methods Totally 193 patients with oligoasthenospermia were divided into three groups according to the open, self-controlled clinical research method. The control group （ 60 cases ） received Vitamin E Tablets （ 1 tablet/time, 3 times/d ） , the treatment group （ 70 cases ） received Huanshao Capsules （ 3 capsules/time, 3 times /d ） , the combination group （ 63 cases ） received Huanshao Capsules （ 3 capsules/time, 3 times/d ） and Vitamin E Tablets （ 1 tablet/time, 3 times/d ） . The 3 groups were treated for 12 weeks. Results Totally 184 patients finished the clinical research. After 4, 8, 12 weeks of treatment, the indexes of the treatment group and the combination group were improved in varying degrees, and the pregnancy rates of the spouse were significantly improved. After 12 weeks of treatment, the sperm density of the treatment group increased by 74. 78%, and that of the combination group increased by 83. 48%. the grade a and b sperms of the treat-ment group increased by 98. 74%, and that of the combination group increased by 103. 72%, the grade a sperms of the treatment group increased by 95. 64%, and that of the combination group increased by 94. 97%, the sperm motility rate of the treatment group increased by 72. 26%, and that of the combination group increased by 73. 93%, the semen volume of the treatment group increased by 30. 99%, and that of the combination group increased by 29. 67%, the semen liquefaction time of the treatment group decreased by 39. 90%, that of the combination group decreased by 39. 41%, the normal sperm morphology of the treatment group increased by 160. 80%, and that of the combination group increased by 178. 87%, the fructose content in semen of the treatment group and the combination group in-creased by 38. 08% and 40. 90%, respectively, the α-glucosidase activity of the treatment group and the combination group increased by 41. 75% and 41. 66% , respectively, the pregnancy rates of the treatment group and the combination group were 19. 70% and 19. 67%, respectively. Conclusion Huanshao Capsules can significantly improve the semen quality of patients with oligoasthenospermia, improve the pregnancy rate of the spouse, and there is no obvious adverse reaction.
出处
《中国药业》
CAS
2017年第23期42-44,共3页
China Pharmaceuticals
关键词
还少胶囊
少弱精子
中成药
脾肾同调
疗效
Huanshao Capsules
oligoasthenospermia
Chinese patent medicine
simultaneous treatment of spleen and kidney
curative effect
