摘要
溃疡性结肠炎(UC)是炎症性肠病的主要类型,发病率逐年升高,其发病机制复杂,诊断和病情评估需要依赖结肠镜检查。近年来发现microRNAs通过调节特定mRNAs的蛋白质翻译过程来调节基因的表达,参与调控细胞分化、凋亡和炎症过程,特别是组织和循环血液中microRNAs参与调节UC的发病和病情活动。部分microRNAs可能成为很有前景的UC生物标志物。
Ulcerative colitis is the main type of inflammatory bowel diseases with an increasingincidence by years. The pathogenesis is complex, its diagnosis and evaluation depend on colonoscopy. Inrecent years,microRNAs have been proved to be participating in regulating target mRNAs which modify geneexpression,regulate cell differentiation, apoptosis and inflammation. Tissue and circulating microRNAs arefound to be related to the pathogenesis and inflammatory activity of ulcerative colitis. MicroRNAs arepromising biomarker in ulcerative colitis.
出处
《中华诊断学电子杂志》
2017年第4期217-220,共4页
Chinese Journal of Diagnostics(Electronic Edition)
