摘要
目的观察补中益气汤加减治疗亚临床甲状腺功能减退症的近期和远期疗效及其安全性。方法将120例亚临床甲状腺功能减退症患者随机分为治疗组和对照组,每组60例。分别给予补中益气汤加减治疗和优甲乐治疗各3个月,并随访观察12个月,比较两组治疗前后甲状腺功能、症状积分和随访过程中甲状腺功能变化。结果对照组和治疗组分别脱落12、6例。与治疗前相比,两组治疗后各时点血清促甲状腺激素水平均显著降低(P<0.05);随访过程中治疗组各时点血清促甲状腺激素水平均维持在4.0μIU/mL以下,始终显著低于同时点对照组(P<0.05);治疗组治疗后乏力、怕冷、颈部憋闷、手脚肿胀感、腹胀、甲状腺肿积分及总积分均低于治疗前(P<0.05);对照组治疗后乏力、颈部憋闷、腹胀、甲状腺肿积分及总积分较治疗前明显下降(P<0.05),怕冷、手脚肿胀感治疗前后未见明显变化(P>0.05);两组患者治疗前后各症状积分及总积分差值比较,差异均有统计学意义(P<0.05)。随访12个月后,治疗组预后转归明显优于对照组(P<0.05)。两组均无明显不良反应。结论补中益气汤加减治疗亚临床甲状腺功能减退症具有良好的近期和远期疗效及安全性。
Objective To investigate the short- and long-term efficacy and safety of Modified Buzhong Yiqi Decoc- tion in the treatment of subclinical hypothyroidism. Methods A total of 120 patients with subclinical hypothyroidism were randomly divided into treatment group and control group, with 60 patients in each group. The patients in the treatment group were given Modified Buzhong Yiqi Decoction, and those in the control group were given Euthyrox. The course of treatment was 3 months for both groups. Both groups were followed up for 12 months and were com- pared in terms of thyroid function and symptom score before and after treatment, as well as the change in thyroid function during follow-up. Results A total of 12 patients in the control group and 6 in the treatment group were lost. Both groups had a significant reduction in thyroid-stimulating hormone （TSH） at each time point after treatment （P〈0. 05）. During follow-up, the treatment group had a serum level of TSH maintained below 4 /dU/mL at each time point and had a significantly lower level than the control group （P〈0. 05）. The treatment group had significant re- ductions in the scores of weakness, fear of cold, oppression in the neck, swelling in the hands and feet, abdominal distension, and goiter and the total symptom score after treatment （P〈0.05）; the control group had significant re- ductions in the scores of weakness, oppression in the neck, abdominal distension, and goiter and the total symptom score after treatment （P〈0. 05）, while there were no significant changes in the scores of fear of cold and swelling in the hands and feet （P〈0. 05）. There were significant differences between＇the two groups with respect to the changes in the score of each symptom and the total symptom score after treatment （P〈0.05）. After the 12-month follow-up, the treatment group had significantly better prognosis than the control group （P〈0. 05）. There were no significant adverse reactions in either group. Conclusion Modified Buzhong Yiqi Decoction has good short- and long-term efficacy and safety in the treatment of subclinical hypothyroidism.
出处
《安徽中医药大学学报》
2017年第6期30-34,共5页
Journal of Anhui University of Chinese Medicine
