摘要
目的探讨中国人群胃癌发病的影响因素,为胃癌的预防控制提供参考依据。方法检索中国生物医学文献数据库(CBM)、维普中文科技期刊数据库(VIP)、中国学术文献总库(CNKI)和万方数据库,并辅以手工检索和文献追溯法收集1998年1月—2015年12月公开发表的关于中国人群胃癌发病影响因素的相关文献;应用RevMan 5.2软件对纳入的文献进行meta分析。结果最终纳入39篇中文文献,累计病例组患者8 979例,对照组人群11 593人;meta分析结果显示,吸烟(OR=2.79,95%CI=2.41~3.24)、喜食腌制食品(OR=2.48,95%CI=2.16~2.85)、饮食不规律(OR=2.46,95%CI=2.08~2.92)、有消化系统疾病史(OR=6.85,95%CI=3.98~11.79)、饮酒(OR=2.63,95%CI=2.04~3.38)、重盐饮食(OR=2.58,95%CI=2.09~3.20)、喜食煎炸食品(OR=2.28,95%CI=1.87~2.78)、喜食烫食(OR=2.67,95%CI=2.12~3.37)、有肿瘤家族史(OR=4.50,95%CI=3.64~5.56)、喜食熏制食品(OR=2.86,95%CI=2.02~4.04)、有幽门螺杆菌感染(OR=2.48,95%CI=1.60~3.86)、进食速度快(OR=2.60,95%CI=2.06~3.30)、暴饮暴食(OR=2.30,95%CI=1.75~3.02)、喜食干硬食品(OR=3.99,95%CI=2.51~6.35)和喜食辣食(OR=2.64,95%CI=1.60~4.35)是中国人群胃癌发病的危险因素,常吃蔬菜(OR=0.58,95%CI=0.49~0.68)、常饮茶(OR=0.52,95%CI=0.42~0.64)、常吃豆及豆制品(OR=0.49,95%CI=0.36~0.67)、常吃葱蒜(OR=0.37,95%CI=0.24~0.56)、常吃奶及奶制品(OR=0.63,95%CI=0.51~0.79)和常吃水果(OR=0.56,95%CI=0.48~0.65)是中国人群胃癌发病的的保护因素;敏感性分析和发表偏倚评估结果显示,纳入的文献不存在发表偏倚,结果较为可靠。结论吸烟饮酒情况、家族史、疾病史和饮食习惯均为中国胃癌发病的主要影响因素。
Objective To explore main factors related to the incidence of gastric cancer in Chinese population and to provide evidences for gastric cancer prevention and control. Methods Studies on relative factors for gastric cancer in- cidence published between January 1998 and December 2015 were retrieved through Chinese Biomedical Literature Data- base （CBM）, Chinese Science and Technology Journal Database （VIP）, Chinese Academic Library, China National Knowledge Infrastructure （CNKI）, and Wanfang Database and supplemental manual search and traceability search were also conducted. A meta-analysis on the included literatures was performed using RevMan 5.2. Results Totally 39 litera- tures published in Chinese were included,involving 8 979 cases and 11 593 controls. The results of meta-analysis showed that the risk factors of gastric cancer incidence were smoking （odds ratio E OR] =2. 79,95% confidence interval I95% CII = 2. 41 - 3.24 ）, preference for pickled food （ OR = 2.48,95 % CI = 2. 16 - 2. 85 ）, irregular dietary behaviors （ OR = 2. 46, 95 % CI = 2.08 - 2.92 ） , digestive system disease （ OR = 6. 85,95 % CI = 3.98 - 11.79 ）, alcohol drinking （ OR = 2.63, 95 % CI = 2.04 - 3.38 ）, having salty food （ OR = 2. 58,95 % CI = 2. 09 - 3.20 ）, preference for fried food （ OR = 2. 28, 95% CI = 1.87 - 2.78 ）, preference for hot food （ OR = 2. 67,95% CI = 2. 12 - 3.37 ）, family history of cancer （ OR = 4. 50,95 % C1 = 3.64 - 5. 56）, preference for smoked food （ OR = 2. 86,95 % CI = 2. 02 - 4. 04）, with infection of Helico- bacter pylori （ OR = 2. 48,95 % CI = 1.60 - 3.86 ）, fast eating behavior （ OR = 2. 60,95 % CI = 2. 06 - 3.30 ）, overeating （ OR = 2. 30,95 % CI = 1.75 - 3.02）, preference for dry and hard food （ OR = 3.99,95 % CI = 2. 51 - 6. 35 ）, and prefer- ence for spicy food （ OR = 2. 64,95 % CI = 1.60 - 4. 35 ） ; while the protective factors were frequent vegetable intake （ OR =0. 58,95% CI=O. 49 -0. 68） ,drinking tea frequently （ OR = O. 52,95% CI = O. 42 - O. 64） ,frequent intake of beans and soy products （ OR = O. 49,95 % CI = O. 36 - O. 67）, eating garlic frequently （ OR = O. 37,95 % CI = O. 24 - O. 56 ）, fre- quent consumption of milk and milk products （ OR = O. 63,95% CI = O. 51 - O. 79 ）, and taking fruits frequently （ OR = O. 56,95 % CI = O. 48 -O. 65 ）. Sensitivity and publication bias analysis showed that there was no publication bias for the literatures included and the results were reliable. Conclusion Smoking, alcohol consumption, family history, disease his- tory and eating habits are the main factors affecting the incidence of gastric cancer in Chinese population.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2017年第12期1775-1780,共6页
Chinese Journal of Public Health
关键词
胃癌
发病
影响因素
中国人群
META分析
gastric cancer
incidence
influencing factor
Chinese population
meta-analysis
