摘要
以羧甲基壳聚糖为原料,与3-氯-2-羟丙基三甲基氯化铵、乳糖反应,用KBH4还原,合成半乳糖季铵化羧甲基壳聚糖,并对其进行结构表征、测定其氨基取代度与溶解性能。结果显示,合成产物IR中有出现三甲基季铵离子中的-CH3吸收峰,NMR中有三甲基季铵离子中的-CH3吸收峰,并有3处出现半乳糖基上的相邻-OH所裂分的双峰,氨基取代度为55.7%,在水中溶解性能较好。结果表明,该方法可合成半乳糖季铵化羧甲基壳聚糖。
N-trimethyl carboxymethyl chitosan was produced by carboxymethyl chitosan and 3-chloro-2-hydroxypropyltrimethylammonium chloride,then it reacted with lactose in its NH2 and KBH4,galactosylated N-trimethyl carboxymethyl chitosan was produced,the chemical structures of galactosylated N-trimethyl carboxymethyl chitosan were characterized by FTIR and1 H-NMR, result proved the synthesis was successful. Galactosylated N-trimethyl carboxymethyl chitosan may be used as drug delivery carriers for hepatocyte-targeting.
出处
《广州化工》
CAS
2017年第22期23-26,共4页
GuangZhou Chemical Industry
基金
广东省社会发展领域科技计划项目(No:0903129)
关键词
羧甲基壳聚糖
半乳糖季铵化羧甲基壳聚糖
乳糖
合成
靶向性载体
carboxymethyl chitosan
galactosylated N - trimethyl carboxymethyl chitosan
lactose
synthesis
targeted drug carrier
