摘要
目的探讨完全缓解期急性髓性白血病采用自体骨髓移植治疗的临床疗效及可行性。方法将58例完全缓解期急性髓性白血病患者按照治疗方法不同分为观察组和对照组,每组29例。观察组采用自体骨髓移植治疗,对照组采用常规临床治疗,随访3年,比较2组患者住层流病房时间、造血恢复时间、复发时间及并发症发生情况。结果观察组患者骨髓有核细胞(ANC)>0.5×109 L-1恢复时间、血小板>20.0×109 L-1恢复时间和住层流病房时间均较对照组显著缩短(P<0.01),复发时间较对照组显著延长(P<0.01);观察组术后并发症发生率较对照组显著减少(6.9%比31.0%,P<0.05)。结论完全缓解期急性髓性白血病采用自体骨髓移植治疗能显著改善患者的造血重建功能,延缓复发,且并发症发生率低。
Objective To explore the clinical efficacy and feasibility of autologous bone marrow transplantation in the treatment of acute myeloid leukemia in complete remission.Methods Fiftyeight patients with acute myeloid leukemia in complete remission were assigned to receive either autologous bone marrow transplantation(observation group,n=29)or routine clinical treatment(control group,n=29).Patients were followed up for 3 years.The laminar air flow unit stay,hematopoietic recovery time,recurrence time and complications were compared between the two groups.Results Compared with control group,autologous bone marrow transplantation shortened the recovery time of nucleated bone marrow cells(ANC)>0.5×109 L-1 and platelets>20.0×109 L-1 and the length of laminar air flow unit stay(P<0.01),prolonged the time of recurrence(P<0.01),and reduced the incidence of postoperative complications(6.9%vs 31.0%,P<0.05).Conclusion Autologous bone marrow transplantation can enhance hematopoietic function,delay recurrence and reduce complications in patients with acute myeloid leukemia in complete remission.
出处
《实用临床医学（江西）》
CAS
2017年第10期13-15,共3页
Practical Clinical Medicine
关键词
急性髓性白血病
自体骨髓移植
临床疗效
acute myeloid leukemia
autologous bone marrow transplantation
clinical efficacy
