摘要
目的探讨缺氧诱导因子-1α(HIF-1α)、葡萄糖转运蛋白-1(Glut-1)及血管内皮生长因子(VEGF)在皮肤鳞状细胞癌(SCC)及基底细胞癌(BCC)中的表达。方法免疫组织化学法检测43例SCC标本、109例BCC标本、30例正常皮肤组织标本中HIF-1α、Glut-1、VEGF的表达,并分析三者之间的相关性。结果 SCC及BCC中HIF-1α、Glut-1及VEGF阳性表达率显著高于正常皮肤组织(P<0.05);SCC中HIF-1α、Glut-1及VEGF阳性表达率显著高于BCC(P<0.05)。SCC中HIF-1α、Glut-1及VEGF表达与SCC分化程度无关,但3个指标表达两两呈现正相关关系(P<0.05)。结论 HIF-1α、Glut-1及VEGF在SCC及BCC中高表达,三者的表达可为SCC及BCC的诊断提供判断依据。
Objective To investigate the expression of hypoxia-inducioble factor-1α（HIF-1α）,glucose transporter-1（Glut-1）and vascular endothelial growth factor（VEGF）in squamous cell carcinoma（SCC）and basal cell carcinoma（BCC）.Methods The expression of HIF-1α,Glut-1 and VEGF was used to detected by immunohistochemistry in 43 cases of SCC,109 cases of BCC and 30 cases of normal skin tissue,and to analyze the correlation between them.Results The expression of HIF-1α,Glut-1 and VEGF in SCC and BCC tissue was significantly higher than that in normal skin tissue（P〈0.05）.The expression of HIF-1α,Glut-1 and VEGF in SCC tissue was significantly higher than that in BCC tissue（P〈0.05）.The expression of HIF-1α,Glut-1 and VEGF in SCC tissue was not correlated with the degree of tumor differentiation.The expression of HIF-1α,Glut-1 and VEGF presented positive correlation with each other（P〈0.05）.Conclusion HIF-1α,Glut-1 and VEGF are highly expressed in SCC and BCC,and the expression of three indicators could provide a basis for the diagnosis of SCC and BCC.
出处
《检验医学与临床》
CAS
2017年第23期3515-3516,3519,共3页
Laboratory Medicine and Clinic
