摘要
目的:系统评价活血化瘀法联合西药治疗儿童支气管哮喘的临床疗效。方法:采用计算机检索中国知网(CNKI)、重庆维普中文数据库(VIP)、中国生物医学文献数据库(CBM)、Pubmed数据库等中英文数据库,并使用RevMan5.3软件进行Meta分析。结果:最终共7篇文献纳入,Meta分析结果显示活血化瘀法联合西药治疗儿童哮喘的总体有效率明显优于单用西药治疗组,合并OR=3.64,95%CI=(1.70,7.77),统计量Z=3.34(P=0.0009),差异有统计学意义;活血化瘀法联合西药治疗儿童哮喘的临床控制率明显优于单用西药治疗组,合并OR=3.15,95%CI=(2.11,4.69),统计量Z=5.62(P=0.00001),差异有统计学意义。结论:现有临床证据表明活血化瘀法联合西药治疗儿童支气管哮喘可提高临床疗效,但由于纳入样本量有限,且其方法学质量评价普遍偏低,尚需要进一步开展更多高质量的深入研究。
Objective： To evaluate the effect of promoting blood circulation and removing stasis therapy combined with western medicine in the treatment of childhood asthma with the method of RCT Meta-analysis. Methods： Electronic databases searched by computer were come from CNKI, VIP, CBM and Pubmed. Meta-analysis was processed by Revman5.3. Results： A total of 7 RCTs involving 542 patients were included. The results of the Meta-analysis showed that compared with the western medicine alone,blood-stasis-removing TCM combined with western medicine was more effective on efficacy ratio（OR=3.64, 95%CI=（1.70, 7.77）,=3.34（P=0.0009）） and control ratio（OR=3.15, 95%CI=（2.11,4.69）, Z=5.62（P=0.00001））. Conclusion： Based on the existing clinical evidence, blood-stasis-removing TCM combined with western medicine can improve the clinical effects treating the childhood asthma. However, most studies were of lower quality and their sample capacity were limited. Further higher-quality clinical studies are needed.
出处
《中医药临床杂志》
2017年第11期1845-1848,共4页
Clinical Journal of Traditional Chinese Medicine
基金
广东省自然科学基金
血管内皮细胞miRNA在血瘀证形成中的作用机制研究(编号:10151063201000045)
