摘要
本实验以L-丙交酯(L-LA)和ε-己内酯(ε-CL)单体开环聚合得到的共聚物(PCLA)为载体,用O/W乳化溶剂挥发法制备姜黄素微球。并采用正交实验法,考察了药物与聚合物质量比、聚乙醇400(PEG400)的质量分数、乳化搅拌转速、温度对微球载药量的影响。通过对工艺的优化,得出较佳的制备条件为药物与聚合物质量比为40 mg/200 mg、PEG400的质量分数为1%、乳化搅拌转速100 r/min、温度为38℃。所制备的载姜黄素PCLA微球圆整,大小分布均匀,粒径分布较窄,平均粒径为(225.52±0.15)μm、载药量(6.15±0.02)%。
Microspheres of Cur-PCLA were fabricated by oil-in-water solvent evaporation method. The effect of technological parameters such as the volume ratio of drug,stirring speed of the emulsion,the concentration of PEG400 and the temperature on the Cur drug loading of the microspheres was evaluated. Preparation conditions were as follows: quantity of drug was 20 mg,speed of mechanical stirring was 100 r/min,PEG400 concentration was 1%,temperature was 38 ℃.The cur-PCLA microspheres displayed an average particle size of(225. 527±0. 157) μm and(6. 15±0. 02) % drug loading amount,while presenting spherical shape,uniform size distribution and narrow particle size distribution.
出处
《广州化工》
CAS
2017年第23期66-68,共3页
GuangZhou Chemical Industry
基金
杭州师范大学钱江学院2015年度科学研究重点项目-聚环酯增载亲酯药物姜黄素控释脂质体纳米粒的制备及初步性能研究(2015QJJL02)
关键词
姜黄素
载药微球
正交实验
curcumin
drug-loaded microsphere
orthogonal test
